Wenle Li1,2, Haosheng Wang3, Shengtao Dong4, Zhi-Ri Tang5, Longhao Chen6, Xintian Cai7, Zhaohui Hu8, Chengliang Yin9,10,11. 1. Department of Orthopedics, Xianyang Central Hospital, Xianyang, 712000, China. 2. Clinical Medical Research Center, Xianyang Central Hospital, Xianyang, 712000, China. 3. Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, 130000, China. 4. Department of Spine Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, 116000, China. 5. School of Physics and Technology, Wuhan University, Wuhan, 430072, China. 6. Graduate School, Guangxi University of Chinese Medicine, Nanning, 530000, China. 7. Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China. 8. Department of Spinal Surgery, Liuzhou People's Hospital, Liuzhou, 545000, China. 329870376@qq.com. 9. National Engineering Laboratory for Medical Big Data Application Technology, Chinese PLA General Hospital, Beijing, 1000853, China. chengliangyin@163.com. 10. Medical Big Data Research Center, Medical Innovation Research Division of Chinese, PLA General Hospital, Beijing, 1000853, China. chengliangyin@163.com. 11. Faculty of Medicine, Macau University of Science and Technology, Macau, 999078, China. chengliangyin@163.com.
Abstract
PURPOSE: The aim of this work was to investigate the risk factors for cement leakage and new-onset OVCF after Percutaneous vertebroplasty (PVP) and to develop and validate a clinical prediction model (Nomogram). METHODS: Patients with Osteoporotic VCF (OVCF) treated with PVP at Liuzhou People's Hospital from June 2016 to June 2018 were reviewed and met the inclusion criteria. Relevant data affecting bone cement leakage and new onset of OVCF were collected. Predictors were screened using univariate and multi-factor logistic analysis to construct Nomogram and web calculators. The consistency of the prediction models was assessed using calibration plots, and their predictive power was assessed by tenfold cross-validation. Clinical value was assessed using Decision curve analysis (DCA) and clinical impact plots. RESULTS: Higher BMI was associated with lower bone mineral density (BMD). Higher BMI, lower BMD, multiple vertebral fractures, no previous anti-osteoporosis treatment, and steroid use were independent risk factors for new vertebral fractures. Cement injection volume, time to surgery, and multiple vertebral fractures were risk factors for cement leakage after PVP. The development and validation of the Nomogram also demonstrated the predictive ability and clinical value of the model. CONCLUSIONS: The established Nomogram and web calculator (https://dr-lee.shinyapps.io/RefractureApp/) (https://dr-lee.shinyapps.io/LeakageApp/) can effectively predict the occurrence of cement leakage and new OVCF after PVP.
PURPOSE: The aim of this work was to investigate the risk factors for cement leakage and new-onset OVCF after Percutaneous vertebroplasty (PVP) and to develop and validate a clinical prediction model (Nomogram). METHODS: Patients with Osteoporotic VCF (OVCF) treated with PVP at Liuzhou People's Hospital from June 2016 to June 2018 were reviewed and met the inclusion criteria. Relevant data affecting bone cement leakage and new onset of OVCF were collected. Predictors were screened using univariate and multi-factor logistic analysis to construct Nomogram and web calculators. The consistency of the prediction models was assessed using calibration plots, and their predictive power was assessed by tenfold cross-validation. Clinical value was assessed using Decision curve analysis (DCA) and clinical impact plots. RESULTS: Higher BMI was associated with lower bone mineral density (BMD). Higher BMI, lower BMD, multiple vertebral fractures, no previous anti-osteoporosis treatment, and steroid use were independent risk factors for new vertebral fractures. Cement injection volume, time to surgery, and multiple vertebral fractures were risk factors for cement leakage after PVP. The development and validation of the Nomogram also demonstrated the predictive ability and clinical value of the model. CONCLUSIONS: The established Nomogram and web calculator (https://dr-lee.shinyapps.io/RefractureApp/) (https://dr-lee.shinyapps.io/LeakageApp/) can effectively predict the occurrence of cement leakage and new OVCF after PVP.
Authors: C A H Klazen; A Venmans; J de Vries; W J van Rooij; F H Jansen; M C Blonk; P N M Lohle; J R Juttmann; E Buskens; K J van Everdingen; A Muller; H Fransen; O E Elgersma; W P Th M Mali; H J J Verhaar Journal: AJNR Am J Neuroradiol Date: 2010-07-22 Impact factor: 3.825
Authors: Caroline A H Klazen; Paul N M Lohle; Jolanda de Vries; Frits H Jansen; Alexander V Tielbeek; Marion C Blonk; Alexander Venmans; Willem Jan J van Rooij; Marinus C Schoemaker; Job R Juttmann; Tjoen H Lo; Harald J J Verhaar; Yolanda van der Graaf; Kaspar J van Everdingen; Alex F Muller; Otto E H Elgersma; Dirk R Halkema; Hendrik Fransen; Xavier Janssens; Erik Buskens; Willem P Th M Mali Journal: Lancet Date: 2010-08-09 Impact factor: 79.321
Authors: G Michael Mallow; David Zepeda; Timothy G Kuzel; J Nicolas Barajas; Khaled Aboushaala; Michael T Nolte; Alejandro Espinoza-Orias; Chundo Oh; Matthew Colman; Monica Kogan; Frank M Phillips; Howard S An; Dino Samartzis Journal: Eur Spine J Date: 2022-02-07 Impact factor: 2.721