Qiong Wu1, Yanhui Qu1, Yi Li1, Yilun Liu1, Jian Shen1, Yan Wang1. 1. Department of Ultrasound in Medicine, Affiliated Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.
Abstract
BACKGROUND: Follicular thyroid carcinoma (FTC) is prone to recurrence and hematogenous metastasis, preoperative accurate diagnosis is still needed to help clinicians select the best surgical methods to improve the prognosis of patients. The aim of this study was to find specific conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) characteristics of FTC and to explore their diagnostic value in the differential diagnosis between FTC and follicular adenoma (FA). METHODS: This retrospective study included 258 thyroid follicular neoplasms (172 FAs and 86 FTCs) in 244 consecutive patients who underwent preoperative conventional US, and 72 of them underwent both conventional US and CEUS. Sonograms were reviewed in consensus by two experienced radiologists for various conventional US and CEUS features. Multivariate logistic regression analysis was performed to determine independent risk factors for FTC. RESULTS: Independent risk factors of conventional US for FTC were heterogenicity (OR =7.477, 95% CI: 2.848-19.629), unevenly thick halo (OR =5.643, 95% CI: 3.234-9.848) and calcifications (OR =1.748, 95% CI: 1.098-2.783). While independent risk factors determined with the combination of CEUS and conventional US were unevenly thick halo (OR =5.770, 95% CI: 1.310-25.409) and absent or irregular rim enhancement (OR =27.000, 95% CI: 2.445-298.178). The area under the receiver operating characteristic curve of the final two logistic regression models was 0.835 and 0.838. CONCLUSIONS: Conventional US is an efficient diagnostic tool in the differential diagnosis of FTC and FA to help clinicians in making appropriate decisions while CEUS failed to provide additional diagnostic value in the study, thus the value of CEUS remains to be verified by further studies with larger sample sizes. 2021 Gland Surgery. All rights reserved.
BACKGROUND: Follicular thyroid carcinoma (FTC) is prone to recurrence and hematogenous metastasis, preoperative accurate diagnosis is still needed to help clinicians select the best surgical methods to improve the prognosis of patients. The aim of this study was to find specific conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) characteristics of FTC and to explore their diagnostic value in the differential diagnosis between FTC and follicular adenoma (FA). METHODS: This retrospective study included 258 thyroid follicular neoplasms (172 FAs and 86 FTCs) in 244 consecutive patients who underwent preoperative conventional US, and 72 of them underwent both conventional US and CEUS. Sonograms were reviewed in consensus by two experienced radiologists for various conventional US and CEUS features. Multivariate logistic regression analysis was performed to determine independent risk factors for FTC. RESULTS: Independent risk factors of conventional US for FTC were heterogenicity (OR =7.477, 95% CI: 2.848-19.629), unevenly thick halo (OR =5.643, 95% CI: 3.234-9.848) and calcifications (OR =1.748, 95% CI: 1.098-2.783). While independent risk factors determined with the combination of CEUS and conventional US were unevenly thick halo (OR =5.770, 95% CI: 1.310-25.409) and absent or irregular rim enhancement (OR =27.000, 95% CI: 2.445-298.178). The area under the receiver operating characteristic curve of the final two logistic regression models was 0.835 and 0.838. CONCLUSIONS: Conventional US is an efficient diagnostic tool in the differential diagnosis of FTC and FA to help clinicians in making appropriate decisions while CEUS failed to provide additional diagnostic value in the study, thus the value of CEUS remains to be verified by further studies with larger sample sizes. 2021 Gland Surgery. All rights reserved.
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