Literature DB >> 3479980

Phorbol-ester-induced alterations of free calcium ion transients in single rat hepatocytes.

N M Woods1, K S Cuthbertson, P H Cobbold.   

Abstract

The effect of the phorbol esters phorbol 12-myristate 13-acetate (TPA) and phorbol 12,13-dibutyrate (PDB) on changes in free Ca2+ concentration ([Ca2+]i) in single rat hepatocytes, microinjected with the photoprotein aequorin, were investigated. [Arg8]vasopressin and phenylephrine induced a series of repetitive [Ca2+]i transients. Phorbol esters inhibited the alpha 1-adrenoceptor-induced response; sub-nanomolar concentrations decreased the transient frequency, and higher concentrations abolished the transients. The inhibitory effect of PDB was readily reversible. Phorbol esters were less effective in decreasing the frequency of [Arg8]-vasopressin-induced transients, and the inhibition could be overcome by high [Arg8]vasopressin concentrations.

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Year:  1987        PMID： 3479980      PMCID： PMC1148325          DOI： 10.1042/bj2460619

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes.

Authors:  N M Woods; K S Cuthbertson; P H Cobbold
Journal:  Cell Calcium       Date:  1987-02       Impact factor: 6.817

2.  Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system.

Authors:  Y Takai; A Kishimoto; U Kikkawa; T Mori; Y Nishizuka
Journal:  Biochem Biophys Res Commun       Date:  1979-12-28       Impact factor: 3.575

3.  Evidence from aequorin for injury of metabolically inhibited myocytes independently of free Ca2+.

Authors:  P H Cobbold; P K Bourne; S R Cuthbertson
Journal:  Basic Res Cardiol       Date:  1985       Impact factor: 17.165

4.  4 beta-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes.

Authors:  J M Staddon; R G Hansford
Journal:  Biochem J       Date:  1986-09-15       Impact factor: 3.857

5.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

6.  Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes.

Authors:  N M Woods; K S Cuthbertson; P H Cobbold
Journal:  Nature       Date:  1986 Feb 13-19       Impact factor: 49.962

7.  Effects of quinine and apamin on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells.

Authors:  G M Burgess; M Claret; D H Jenkinson
Journal:  J Physiol       Date:  1981-08       Impact factor: 5.182

8.  Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

Authors:  K L Leach; M L James; P M Blumberg
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

9.  Inhibition of insulin receptor binding by phorbol esters.

Authors:  P Thomopoulos; U Testa; M F Gourdin; C Hervy; M Titeux; W Vainchenker
Journal:  Eur J Biochem       Date:  1982-12-15

10.  Aequorin measurements of free calcium in single mammalian cells.

Authors:  P H Cobbold; K S Cuthbertson; M H Goyns; V Rice
Journal:  J Cell Sci       Date:  1983-05       Impact factor: 5.285
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  26 in total

1.  Frequency encoding in excitable systems with applications to calcium oscillations.

Authors:  Y Tang; H G Othmer
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

2.  Suppression of agonist induced Ca2+ oscillations in cultured hepatocytes by nafenopin: possible involvement of protein kinase C.

Authors:  E Leibold; A Stampfl; L R Schwarz
Journal:  Arch Toxicol       Date:  1996       Impact factor: 5.153

3.  Receptor-mediated endocytosis of asialoglycoproteins and diferric transferrin is independent of second messengers.

Authors:  R J Sharma; N M Woods; P H Cobbold; D A Grant
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857

4.  Abnormal protein kinase C down regulation and reduced substrate levels in non-phorbol ester-responsive 3T3-TNR9 cells.

Authors:  H P Biemann; R L Erikson
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

5.  Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte.

Authors:  A Sanchez-Bueno; C J Dixon; N M Woods; K S Cuthbertson; P H Cobbold
Journal:  Biochem J       Date:  1990-06-15       Impact factor: 3.857

6.  The effect of external calcium and pH on inositol trisphosphate-mediated calcium release from cerebellum microsomal fractions.

Authors:  S K Joseph; H L Rice; J R Williamson
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

7.  Modulation of Ca2+ oscillation and apamin-sensitive, Ca2+-activated K+ current in rat gonadotropes.

Authors:  A Tse; F W Tse; B Hille
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

8.  Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.

Authors:  U K Misra; C T Chu; D S Rubenstein; G Gawdi; S V Pizzo
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

9.  Effects of GTP gamma S on muscarinic receptor-stimulated inositol phospholipid hydrolysis in permeabilized smooth muscle from the small intestine.

Authors:  S A Prestwich; H Miyazaki; T B Bolton
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

10.  Homologous and heterologous desensitization of histamine H1- and ATP-receptors in the smooth muscle cell line, DDT1MF-2: the role of protein kinase C.

Authors:  J M Dickenson; S J Hill
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739
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