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Literature DB >> 3478708

Spin glasses and the statistical mechanics of protein folding.

Abstract

The theory of spin glasses was used to study a simple model of protein folding. The phase diagram of the model was calculated, and the results of dynamics calculations are briefly reported. The relation of these results to folding experiments, the relation of these hypotheses to previous protein folding theories, and the implication of these hypotheses for protein folding prediction schemes are discussed.

Entities: Gene

Mesh：

Substances：
Proteins

Year: 1987 PMID： 3478708 PMCID： PMC299331 DOI： 10.1073/pnas.84.21.7524

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. A model of protein conformational substates.

Authors: D L Stein
Journal: Proc Natl Acad Sci U S A Date: 1985-06 Impact factor: 11.205

2. Optimization by simulated annealing.

Authors: S Kirkpatrick; C D Gelatt; M P Vecchi
Journal: Science Date: 1983-05-13 Impact factor: 47.728

3. Phenomenological description of the association of protein subunits subjected to conformational drift. Effects of dilution and of hydrostatic pressure.

Authors: G Weber
Journal: Biochemistry Date: 1986-06-17 Impact factor: 3.162

4. Nucleation, rapid folding, and globular intrachain regions in proteins.

Authors: D B Wetlaufer
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

5. Protein states and proteinquakes.

Authors: A Ansari; J Berendzen; S F Bowne; H Frauenfelder; I E Iben; T B Sauke; E Shyamsunder; R D Young
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

6. Principles that govern the folding of protein chains.

Authors: C B Anfinsen
Journal: Science Date: 1973-07-20 Impact factor: 47.728

7. Recent progress in the theoretical treatment of protein folding.

Authors: H A Scheraga
Journal: Biopolymers Date: 1983-01 Impact factor: 2.505

8. 'Molten-globule state': a compact form of globular proteins with mobile side-chains.

Authors: M Ohgushi; A Wada
Journal: FEBS Lett Date: 1983-11-28 Impact factor: 4.124

9. Prediction of the native conformation of a polypeptide by a statistical-mechanical procedure. I. Backbone structure of enkephalin.

Authors: G H Paine; H A Scheraga
Journal: Biopolymers Date: 1985-08 Impact factor: 2.505

10. Folding protein models with a simple hydrophobic energy function: the fundamental importance of monomer inside/outside segregation.

Authors: A F Pereira De Araújo
Journal: Proc Natl Acad Sci U S A Date: 1999-10-26 Impact factor: 11.205

Spin glasses and the statistical mechanics of protein folding.

1. A model of protein conformational substates.

2. Optimization by simulated annealing.

3. Phenomenological description of the association of protein subunits subjected to conformational drift. Effects of dilution and of hydrostatic pressure.

4. Nucleation, rapid folding, and globular intrachain regions in proteins.

5. Protein states and proteinquakes.

6. Principles that govern the folding of protein chains.

7. Recent progress in the theoretical treatment of protein folding.

8. 'Molten-globule state': a compact form of globular proteins with mobile side-chains.

9. Prediction of the native conformation of a polypeptide by a statistical-mechanical procedure. I. Backbone structure of enkephalin.

10. Alpha-Lactalbumin: compact state with fluctuating tertiary structure?

1. Deciphering the folding kinetics of transmembrane helical proteins.

2. Conformational propagation with prion-like characteristics in a simple model of protein folding.

3. Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space.

4. A simple model for calculating the kinetics of protein folding from three-dimensional structures.

5. Hierarchies and logarithmic oscillations in the temporal relaxation patterns of proteins and other complex systems.

6. A statistical mechanical method to optimize energy functions for protein folding.

7. Investigation of routes and funnels in protein folding by free energy functional methods.

8. Protein folding and unfolding on a complex energy landscape.

9. RNA folding energy landscapes.

10. Folding protein models with a simple hydrophobic energy function: the fundamental importance of monomer inside/outside segregation.