Literature DB >> 3477129

Genetic susceptibility to toxic epidermal necrolysis.

J C Roujeau, T N Huynh, C Bracq, J C Guillaume, J Revuz, R Touraine.   

Abstract

The pathophysiologic events leading to toxic epidermal necrolysis (TEN) remain unknown. With the idea of an immunologically mediated reaction occurring in predisposed subjects we performed HLA-A, -B and -DR typing in 44 patients surviving TEN. We observed a significant increase of only HLA-B12, previously found associated with ocular complications of Stevens-Johnson syndrome. When patients were stratified according to the drugs involved as causes for their TEN, we found other HLA phenotypes associated with B12, varying with each category of drugs. Sulfonamide-related cases of TEN were linked to A29, B12, and DR7, while oxicam-related cases of TEN were linked to A2 and B12. These results suggest that a genetic background, related to the major histocompatibility complex, may contribute to severe blistering drug reactions.

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Year:  1987        PMID： 3477129

Source DB:  PubMed          Journal:  Arch Dermatol        ISSN： 0003-987X


  45 in total

1.  Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan.

Authors:  Kow-Tong Chen; Shiing-Jer Twu; Hong-Jen Chang; Ruey-Shiung Lin
Journal:  Am J Public Health       Date:  2003-03       Impact factor: 9.308

Review 2.  Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.

Authors:  B K Park; M Pirmohamed; N R Kitteringham
Journal:  Br J Clin Pharmacol       Date:  1992-11       Impact factor: 4.335

3.  [Ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis].

Authors:  Argyrios Chronopoulos; Maja Mockenhaupt; Uwe Pleyer
Journal:  Ophthalmologe       Date:  2021-03-16       Impact factor: 1.059

4.  RIPping the Skin Apart: Necroptosis Signaling in Toxic Epidermal Necrolysis.

Authors:  Diana Panayotova-Dimitrova; Maria Feoktistova; Martin Leverkus
Journal:  J Invest Dermatol       Date:  2015-08       Impact factor: 8.551

5.  Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.

Authors:  Tais H Wakamatsu; Mayumi Ueta; Katsushi Tokunaga; Yukinori Okada; Renata R Loureiro; Karita A Costa; Juliana Maria F Sallum; José Arthur Milhomens; Chikara Inoue; Chie Sotozono; José Álvaro P Gomes; Shigeru Kinoshita
Journal:  JAMA Ophthalmol       Date:  2017-04-01       Impact factor: 7.389

6.  HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.

Authors:  Shuen-Iu Hung; Wen-Hung Chung; Lieh-Bang Liou; Chen-Chung Chu; Marie Lin; Hsien-Ping Huang; Yen-Ling Lin; Joung-Liang Lan; Li-Cheng Yang; Hong-Shang Hong; Ming-Jing Chen; Ping-Chin Lai; Mai-Szu Wu; Chia-Yu Chu; Kuo-Hsien Wang; Chien-Hsiun Chen; Cathy S J Fann; Jer-Yuarn Wu; Yuan-Tsong Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-02       Impact factor: 11.205

Review 7.  Hypersensitivity reactions to non-beta-lactam antibiotics.

Authors:  Stephen A Tilles; Christopher G Slatore
Journal:  Clin Rev Allergy Immunol       Date:  2003-06       Impact factor: 8.667

8.  Fatal toxic epidermal necrolysis in autoimmune polyglandular syndrome type I.

Authors:  A Porzionato; S Zancaner; C Betterle; S D Ferrara
Journal:  J Endocrinol Invest       Date:  2004-05       Impact factor: 4.256

9.  Testing for drug hypersensitivity syndromes.

Authors:  Craig M Rive; Jack Bourke; Elizabeth J Phillips
Journal:  Clin Biochem Rev       Date:  2013-02

10.  Fluconazole induced toxic epidermal necrolysis: a case report.

Authors:  Uchenna R Ofoma; Edward K Chapnick
Journal:  Cases J       Date:  2009-11-20
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