| Literature DB >> 34767757 |
Chloe X Yap1, Anjali K Henders2, Gail A Alvares3, David L A Wood4, Lutz Krause4, Gene W Tyson5, Restuadi Restuadi6, Leanne Wallace2, Tiana McLaren2, Narelle K Hansell7, Dominique Cleary3, Rachel Grove8, Claire Hafekost3, Alexis Harun3, Helen Holdsworth9, Rachel Jellett10, Feroza Khan11, Lauren P Lawson10, Jodie Leslie3, Mira Levis Frenk9, Anne Masi11, Nisha E Mathew11, Melanie Muniandy10, Michaela Nothard9, Jessica L Miller7, Lorelle Nunn6, Gerald Holtmann12, Lachlan T Strike7, Greig I de Zubicaray13, Paul M Thompson14, Katie L McMahon15, Margaret J Wright16, Peter M Visscher6, Paul A Dawson17, Cheryl Dissanayake10, Valsamma Eapen18, Helen S Heussler19, Allan F McRae6, Andrew J O Whitehouse3, Naomi R Wray20, Jacob Gratten21.
Abstract
There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way. We performed a large autism stool metagenomics study (n = 247) based on participants from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project. We found negligible direct associations between ASD diagnosis and the gut microbiome. Instead, our data support a model whereby ASD-related restricted interests are associated with less-diverse diet, and in turn reduced microbial taxonomic diversity and looser stool consistency. In contrast to ASD diagnosis, our dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency. Overall, microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD.Entities:
Keywords: autism; autism spectrum disorder; brain-gut-microbiome axis; diet; gut microbiome; metagenomics; restricted and repetitive behaviors and interests; stool consistency
Mesh：
Year: 2021 PMID： 34767757 DOI： 10.1016/j.cell.2021.10.015
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582