| Literature DB >> 35909184 |
Sadayuki Fujishiro1, Shoji Tsuji1, Shohei Akagawa1, Yuko Akagawa1, Sohsaku Yamanouchi1, Yuko Ishizaki1, Masaki Hashiyada2, Atsushi Akane2, Kazunari Kaneko3.
Abstract
The gut microbiota was reported to differ between children with autism spectrum disorder (ASD) and typically developing (TD) children, and dysbiosis of the gut microbiota in preterm infants is common. Here, we explored the characteristics of gut microbiota in children born preterm with ASD. We performed 16S rRNA gene sequencing using stool samples from ASD children born preterm and TD children born preterm. Alpha diversity was significantly greater in the ASD group. A comparison of beta diversity showed different clusters. Linear discriminant analysis effect size analysis revealed significantly more Firmicutes in the ASD group compared with the TD group. In conclusion, the gut microbiota in children born preterm differs between children with ASD and TD.Entities:
Keywords: Autism spectrum disorder; Dysbiosis; Gut microbiota; Preterm infants
Year: 2022 PMID： 35909184 DOI： 10.1007/s10803-022-05682-0
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257