Reydson Alcides de Lima-Souza1,2, Natália de Magalhães Rodrigues2, João Figueira Scarini1,2, Mário Fernandez Sobral Silva3, Alfio José Tincani3, Erika Said Abu Egal2,4, Albina Altemani2, Fernanda Viviane Mariano5. 1. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. 2. Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. 3. Department of Surgery, Head and Neck Surgery, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. 4. Department of Pathology, School of Medicine, University of Utah (UU), Salt Lake City, UT, USA. 5. Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. fmariano@unicamp.br.
Abstract
PURPOSE: To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG). METHODS: Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases. RESULTS: Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples. CONCLUSIONS: In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.
PURPOSE: To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG). METHODS: Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases. RESULTS: Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples. CONCLUSIONS: In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.
Authors: Fernanda Viviane Mariano; Felipe Fidalgo; André Luís Maion Casarim; Antônio Santos Martins; João Figueira Scarini; Reydson Alcides de Lima Souza; Erika Said Egal; Luiz Paulo Kowalski; Ana Cristina Victorino Krepischi; Albina Altemani Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2019-09-02