Literature DB >> 16778164

Fatty acid synthase and cancer: new application of an old pathway.

Francis P Kuhajda1.   

Abstract

Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer.

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Year:  2006        PMID： 16778164     DOI： 10.1158/0008-5472.CAN-05-4673

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  238 in total

1.  Fatty acid synthase expression and esophageal cancer.

Authors:  Yongli Zhou; Chunyan Niu; Yandong Li; Baohua Gao; Jianyun Zheng; Xiaoli Guo; Weiguo Ma
Journal:  Mol Biol Rep       Date:  2012-06-22       Impact factor: 2.316

2.  Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.

Authors:  Akiko Hanyuda; Yin Cao; Tsuyoshi Hamada; Jonathan A Nowak; Zhi Rong Qian; Yohei Masugi; Annacarolina da Silva; Li Liu; Keisuke Kosumi; Thing Rinda Soong; Iny Jhun; Kana Wu; Xuehong Zhang; Mingyang Song; Jeffrey A Meyerhardt; Andrew T Chan; Charles S Fuchs; Edward L Giovannucci; Shuji Ogino; Reiko Nishihara
Journal:  Eur J Epidemiol       Date:  2017-05-16       Impact factor: 8.082

3.  Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.

Authors:  Michael C Rudolph; Elizabeth A Wellberg; Andrew S Lewis; Kristina L Terrell; Andrea L Merz; N Karl Maluf; Natalie J Serkova; Steven M Anderson
Journal:  J Lipid Res       Date:  2014-04-25       Impact factor: 5.922

4.  Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death.

Authors:  Joy L Little; Frances B Wheeler; Constantinos Koumenis; Steven J Kridel
Journal:  Mol Cancer Ther       Date:  2008-12       Impact factor: 6.261

5.  Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes.

Authors:  Qi-qiang Long; Yong-xiang Yi; Jie Qiu; Chuan-jun Xu; Pei-lin Huang
Journal:  Tumour Biol       Date:  2014-01-17

6.  Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.

Authors:  Fredrick T Harris; S M Jamshedur Rahman; Mohamed Hassanein; Jun Qian; Megan D Hoeksema; Heidi Chen; Rosana Eisenberg; Pierre Chaurand; Richard M Caprioli; Masakazu Shiota; Pierre P Massion
Journal:  Cancer Prev Res (Phila)       Date:  2014-05-12

7.  Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models.

Authors:  Xuan Yin Chen; Hui Bing Ruan; Xin Hua Long; Ai Fen Peng; Long Dian Zhou; Jia Ming Liu; Yang Zhou; Zhi Li Liu
Journal:  Exp Ther Med       Date:  2017-03-29       Impact factor: 2.447

Review 8.  Metabolic Regulation of Apoptosis in Cancer.

Authors:  K Matsuura; K Canfield; W Feng; M Kurokawa
Journal:  Int Rev Cell Mol Biol       Date:  2016-07-30       Impact factor: 6.813

9.  Cohort study of fatty acid synthase expression and patient survival in colon cancer.

Authors:  Shuji Ogino; Katsuhiko Nosho; Jeffrey A Meyerhardt; Gregory J Kirkner; Andrew T Chan; Takako Kawasaki; Edward L Giovannucci; Massimo Loda; Charles S Fuchs
Journal:  J Clin Oncol       Date:  2008-10-27       Impact factor: 44.544

Review 10.  Pathogenesis of ovarian cancer: clues from selected overexpressed genes.

Authors:  Ie-Ming Shih; Ben Davidson
Journal:  Future Oncol       Date:  2009-12       Impact factor: 3.404
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