Katya Pulido Díaz1, Rogério Gondak2, Leandro Liporoni Martins3, Oslei Paes de Almeida4, Jorge Esquiche León5, Fernanda Viviane Mariano6, Albina Altemani6, Pablo Agustin Vargas4. 1. Universidad Autónoma de Baja California, Escuela de Ciencias de la Salud (UABC-Valle de Las Palmas), Mexicali, Baja California, México. 2. Department of Pathology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil. 3. Department of Pathology, Clinics Hospital University of São Paulo School of Medicine (HC-FMUSP), São Paulo, Brazil. 4. Department of Oral Diagnosis, Oral Pathology, Piracicaba Dental School, State University of Campinas (FOP-UNICAMP), Piracicaba, Brazil. 5. Oral Pathology Section, Department of Stomatology, Public Oral Health, and Forensic Dentistry, University of São Paulo, School of Dentistry of Ribeirão Preto (FORP/USP), Ribeirão Preto, Brazil. 6. Department of Pathology, Faculty of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil.
Abstract
BACKGROUND: Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. METHODS: We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). RESULTS: Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. CONCLUSIONS: The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA.
BACKGROUND:Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. METHODS: We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). RESULTS:Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. CONCLUSIONS: The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA.
Authors: Camila Matsunaga de Angelis; Reydson Alcides de Lima-Souza; João Figueira Scarini; Erika Said Abu Egal; Gleyson Kleber do Amaral-Silva; Rogério de Oliveira Gondak; Oslei Paes de Almeida; Carlos Takahiro Chone; Luiz Paulo Kowalski; Albina Altemani; Fernanda Viviane Mariano Journal: Head Neck Pathol Date: 2021-04-11