Literature DB >> 3475690

Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.

H E Grenett, F D Ledley, L L Reed, S L Woo.   

Abstract

A full-length cDNA for tryptophan hydroxylase was cloned from rabbit pineal body by screening an expression library with antibody against rat phenylalanine hydroxylase, which crossreacts with rabbit tryptophan hydroxylase. Clones producing immunoreactive material contain sequences homologous to, yet distinct from, phenylalanine hydroxylase. The rabbit cDNA hybridizes to mRNA in pineal body and brainstem but not in liver. Comparison of the rabbit tryptophan hydroxylase sequence with the sequences of phenylalanine hydroxylase and tyrosine hydroxylase demonstrates that these three biopterin-dependent aromatic amino acid hydroxylases are highly homologous, reflecting a common evolutionary origin from a single primordial genetic locus. The pattern of sequence homology supports the hypothesis that the carboxyl-terminal two-thirds of the molecules constitute the enzymatic activity cores, and the amino-terminal thirds of the molecules constitute domains for substrate specificity.

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Year:  1987        PMID： 3475690      PMCID： PMC298896          DOI： 10.1073/pnas.84.16.5530

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Activation of brain tryptophan hydroxylase by a phosphorylating system.

Authors:  T W Lysz; P Y Sze
Journal:  J Neurosci Res       Date:  1978       Impact factor: 4.164

2.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

3.  Efficient isolation of genes by using antibody probes.

Authors:  R A Young; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

4.  The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties.

Authors:  J P Abita; M Parniak; S Kaufman
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157

Review 5.  Some properties of bovine pineal tryptophan hydroxylase.

Authors:  A Ichiyama; H Hasegawa; C Tohyama; C Dohmoto; T Kataoka
Journal:  Adv Exp Med Biol       Date:  1976       Impact factor: 2.622

6.  Analysis of chromosomal integration and deletions of yeast plasmids.

Authors:  J R Cameron; P Philippsen; R W Davis
Journal:  Nucleic Acids Res       Date:  1977       Impact factor: 16.971

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties.

Authors:  H Nakata; H Fujisawa
Journal:  Eur J Biochem       Date:  1982-06

9.  Polysome immunoprecipitation of phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA.

Authors:  K J Robson; T Chandra; R T MacGillivray; S L Woo
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

10.  Nucleotide sequence of the rightward operator of phage lambda.

Authors:  T Maniatis; A Jeffrey; D G Kleid
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205
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  45 in total

Review 1.  Mechanism of aromatic amino acid hydroxylation.

Authors:  Paul F Fitzpatrick
Journal:  Biochemistry       Date:  2003-12-09       Impact factor: 3.162

2.  Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.

Authors:  D A Nielsen; M Dean; D Goldman
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025

3.  Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation.

Authors:  G J Yohrling; S M Mockus; K E Vrana
Journal:  J Mol Neurosci       Date:  1999-02       Impact factor: 3.444

4.  Effects of ligands on the mobility of an active-site loop in tyrosine hydroxylase as monitored by fluorescence anisotropy.

Authors:  Giri R Sura; Mauricio Lasagna; Vijay Gawandi; Gregory D Reinhart; Paul F Fitzpatrick
Journal:  Biochemistry       Date:  2006-08-08       Impact factor: 3.162

5.  Tyrosine hydroxylase and tryptophan hydroxylase do not form heterotetramers.

Authors:  S M Mockus; G J Yohrling; K E Vrana
Journal:  J Mol Neurosci       Date:  1998-02       Impact factor: 3.444

6.  A monoclonal antibody to aromatic amino acid hydroxylases. Identification of the epitope.

Authors:  R G Cotton; W McAdam; I Jennings; F J Morgan
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

7.  Substrate regulation of serotonin and dopamine synthesis in Drosophila.

Authors:  Chandra M Coleman; Wendi S Neckameyer
Journal:  Invert Neurosci       Date:  2004-10-06

8.  Kinetic isotope effects on aromatic and benzylic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase as probes of chemical mechanism and reactivity.

Authors:  Aram J Panay; Paul F Fitzpatrick
Journal:  Biochemistry       Date:  2008-09-26       Impact factor: 3.162

9.  Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40.

Authors:  K K Andersson; C Vassort; B A Brennan; L Que; J Haavik; T Flatmark; F Gros; J Thibault
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

Review 10.  Mechanisms of tryptophan and tyrosine hydroxylase.

Authors:  Kenneth M Roberts; Paul F Fitzpatrick
Journal:  IUBMB Life       Date:  2013-02-26       Impact factor: 3.885
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