Literature DB >> 3467650

Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.

W E Stamm, R Suchland.   

Abstract

The MICs of three new antimicrobial agents of different classes, U-70138F, roxithromycin (RU 965), and ofloxacin (ORF 18489), versus Chlamydia trachomatis in McCoy cell cultures were 0.25, 0.8, and 1.0 microgram/ml, respectively. For each test drug, the MIC and MBC were identical or were within 1 dilution of one another. These drugs possessed sufficient activity in cell culture to suggest possible clinical effectiveness.

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Year:  1986        PMID： 3467650      PMCID： PMC176541          DOI： 10.1128/AAC.30.5.806

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  5 in total

1.  Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture.

Authors:  C C Kuo; S P Wang; J T Grayston
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

2.  Comparison of the in vitro activities of ofloxacin and tetracycline against Chlamydia trachomatis as assessed by indirect immunofluorescence.

Authors:  J M Bailey; C Heppleston; S J Richmond
Journal:  Antimicrob Agents Chemother       Date:  1984-07       Impact factor: 5.191

3.  The activity of ciprofloxacin and other 4-quinolones against Chlamydia trachomatis and Mycoplasmas in vitro.

Authors:  G L Ridgway; G Mumtaz; F G Gabriel; J D Oriel
Journal:  Eur J Clin Microbiol       Date:  1984-08       Impact factor: 3.267

4.  Activities of new quinoline derivatives against genital pathogens.

Authors:  J Aznar; M C Caballero; M C Lozano; C de Miguel; J C Palomares; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1985-01       Impact factor: 5.191

5.  Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis.

Authors:  W R Bowie; C K Lee; E R Alexander
Journal:  J Infect Dis       Date:  1978-11       Impact factor: 5.226
  5 in total
  11 in total

1.  Roxithromycin treatment of mouse chlamydial salpingitis and protective effect on fertility.

Authors:  J Zana; M Muffat-Joly; D Thomas; J Orfila; J Salat-Baroux; J J Pocidalo
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

2.  In vitro microbicidal activities of cecropin peptides D2A21 and D4E1 and gel formulations containing 0.1 to 2% D2A21 against Chlamydia trachomatis.

Authors:  L M Ballweber; J E Jaynes; W E Stamm; M F Lampe
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

3.  In vitro activities of T-3262, NY-198, fleroxacin (AM-833; RO 23-6240), and other new quinolone agents against clinically isolated Chlamydia trachomatis strains.

Authors:  H Maeda; A Fujii; K Nakata; S Arakawa; S Kamidono
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

4.  Comparative in vitro activities of pristinamycin and other antimicrobial agents against genital pathogens.

Authors:  J C Lefevre; R Bauriaud
Journal:  Antimicrob Agents Chemother       Date:  1989-12       Impact factor: 5.191

5.  Effects of dirithromycin and erythromycylamine on human neutrophil degranulation.

Authors:  H Abdelghaffar; E M Mtairag; M T Labro
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

6.  In vitro activity of antibiotics against Ureaplasma urealyticum and Chlamydia trachomatis strains from patients with nongonococcal urethritis.

Authors:  F Busolo; L Conventi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1988-06       Impact factor: 3.267

7.  Effects of quinolone analog CI-960 in a monkey model of Chlamydia trachomatis salpingitis.

Authors:  D L Patton; Y T Cosgrove; C C Kuo; L A Campbell
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

8.  In vitro activities of ofloxacin and four other new quinoline-carboxylic acids against Chlamydia trachomatis.

Authors:  A Nagayama; T Nakao; H Taen
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

9.  Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim, and metronidazole into human polymorphonuclear leukocytes.

Authors:  W L Hand; N King-Thompson; J W Holman
Journal:  Antimicrob Agents Chemother       Date:  1987-10       Impact factor: 5.191

Review 10.  Roxithromycin. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.

Authors:  R A Young; J P Gonzalez; E M Sorkin
Journal:  Drugs       Date:  1989-01       Impact factor: 9.546
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