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Literature DB >> 3467350

Evolutionary and genetic implications of sequence variation in two nonallelic HLA-DR beta-chain cDNA sequences.

J M Curtsinger, J M Hilden, J S Cairns, F H Bach.

Abstract

Most HLA haplotypes carry two expressed DR beta-chain genes; in the DR4 haplotype, the polymorphic locus has been called DR beta 1 and the apparently nonpolymorphic locus has been called DR beta 2. We have isolated nearly full-length DR beta-chain cDNA clones representing each of these two loci from a cell line homozygous for DR4 and Dw4. The clones have been sequenced and the sequences compared with published DR beta cDNA sequences derived from other haplotypes. A comparison of our sequences with other published cDNA sequences did not allow assignment of these other sequences to either the beta 1 or beta 2 locus. Comparison of our DR4 beta 1 sequence with DR beta 1 sequences isolated from other DR4-positive cells suggests that the alleles of DR4 beta 1 may have recently diverged from a common ancestor. The apparent lack of polymorphism of DR beta 2 may in part be a reflection of this recent divergence.

Entities: Gene

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Year: 1987 PMID： 3467350 PMCID： PMC304172 DOI： 10.1073/pnas.84.1.209

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

1. Southern analysis of DNA polymorphism among Dw subtypes of DR4.

Authors: J A Nicklas; H J Noreen; M Segall; F H Bach
Journal: Hum Immunol Date: 1985-06 Impact factor: 2.850

2. Intron sequences reveal evolutionary relationships among major histocompatibility complex class I genes.

Authors: H Ronne; E Widmark; L Rask; P A Peterson
Journal: Proc Natl Acad Sci U S A Date: 1985-09 Impact factor: 11.205

3. Structural organization of the DR subregion of the human major histocompatibility complex.

Authors: T Spies; R Sorrentino; J M Boss; K Okada; J L Strominger
Journal: Proc Natl Acad Sci U S A Date: 1985-08 Impact factor: 11.205

4. Characterization of an HLA DR beta pseudogene.

Authors: D Larhammar; B Servenius; L Rask; P A Peterson
Journal: Proc Natl Acad Sci U S A Date: 1985-03 Impact factor: 11.205

5. DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype.

Authors: J I Bell; P Estess; T St John; R Saiki; D L Watling; H A Erlich; H O McDevitt
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

6. Sequence polymorphism of HLA DR beta 1 alleles relating to T-cell-recognized determinants.

Authors: J S Cairns; J M Curtsinger; C A Dahl; S Freeman; B J Alter; F H Bach
Journal: Nature Date: 1985 Sep 12-18 Impact factor: 49.962

Review 7. Generation of class II antigen polymorphism.

Authors: L Rask; K Gustafsson; D Larhammar; H Ronne; P A Peterson
Journal: Immunol Rev Date: 1985-07 Impact factor: 12.988

8. A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.

Authors: R M Dale; B A McClure; J P Houchins
Journal: Plasmid Date: 1985-01 Impact factor: 3.466

3. Human cytomegalovirus in the pancreas of patients with type 2 diabetes: is there a relation to clinical features, mRNA and protein expression of insulin, somatostatin, and MHC class II?

Authors: M Löhr; B Bergstrome; R Maekawa; M B Oldstone; G Klöppel
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1992

3 in total