| Literature DB >> 34672695 |
Kizzmekia S Corbett1, Matthew Gagne1, Danielle A Wagner1, Sarah O' Connell1, Sandeep R Narpala1, Dillon R Flebbe1, Shayne F Andrew1, Rachel L Davis1, Barbara Flynn1, Timothy S Johnston1, Christopher D Stringham1, Lilin Lai2, Daniel Valentin3, Alex Van Ry3, Zackery Flinchbaugh3, Anne P Werner1, Juan I Moliva1, Manjari Sriparna1, Sijy O'Dell1, Stephen D Schmidt1, Courtney Tucker1, Angela Choi4, Matthew Koch4, Kevin W Bock5, Mahnaz Minai5, Bianca M Nagata5, Gabriela S Alvarado1, Amy R Henry1, Farida Laboune1, Chaim A Schramm1, Yi Zhang1, Eun Sung Yang1, Lingshu Wang1, Misook Choe1, Seyhan Boyoglu-Barnum1, Shi Wei1, Evan Lamb1, Saule T Nurmukhambetova1, Samantha J Provost1, Mitzi M Donaldson1, Josue Marquez1, John-Paul M Todd1, Anthony Cook3, Alan Dodson3, Andrew Pekosz6, Eli Boritz1, Aurélie Ploquin1, Nicole Doria-Rose1, Laurent Pessaint3, Hanne Andersen3, Kathryn E Foulds1, John Misasi1, Kai Wu4, Andrea Carfi4, Martha C Nason7, John Mascola1, Ian N Moore5, Darin K Edwards4, Mark G Lewis3, Mehul S Suthar2, Mario Roederer1, Adrian McDermott1, Daniel C Douek1, Nancy J Sullivan1, Barney S Graham1, Robert A Seder1.
Abstract
Neutralizing antibody responses gradually wane against several variants of concern (VOCs) after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine messenger RNA-1273 (mRNA-1273). We evaluated the immune responses in nonhuman primates that received a primary vaccination series of mRNA-1273 and were boosted about 6 months later with either homologous mRNA-1273 or heterologous mRNA-1273.β, which encompasses the spike sequence of the B.1.351 Beta variant. After boost, animals had increased neutralizing antibody responses across all VOCs, which was sustained for at least 8 weeks after boost. Nine weeks after boost, animals were challenged with the SARS-CoV-2 Beta variant. Viral replication was low to undetectable in bronchoalveolar lavage and significantly reduced in nasal swabs in all boosted animals, suggesting that booster vaccinations may be required to sustain immunity and protection.Entities:
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Year: 2021 PMID： 34672695 DOI： 10.1126/science.abl8912
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728