| Literature DB >> 35361968 |
Marciela M DeGrace1,2, Elodie Ghedin1,3, Matthew B Frieman4, Florian Krammer5,6, Alba Grifoni7, Arghavan Alisoltani8, Galit Alter9, Rama R Amara10, Ralph S Baric11,12, Dan H Barouch13, Jesse D Bloom14, Louis-Marie Bloyet15, Gaston Bonenfant16, Adrianus C M Boon17, Eli A Boritz1,2,18, Debbie L Bratt1,2,19, Traci L Bricker17, Liliana Brown1,2, William J Buchser20, Juan Manuel Carreño21, Liel Cohen-Lavi22, Tamarand L Darling17, Meredith E Davis-Gardner23, Bethany L Dearlove24, Han Di16, Meike Dittmann25, Nicole A Doria-Rose1,18, Daniel C Douek1,18, Christian Drosten26, Venkata-Viswanadh Edara23, Ali Ellebedy27, Thomas P Fabrizio28, Guido Ferrari29, Will M Fischer30, William C Florence1,2, Ron A M Fouchier31, John Franks28, Adolfo García-Sastre21,32,33,34,35, Adam Godzik8, Ana Silvia Gonzalez-Reiche36, Aubree Gordon37, Bart L Haagmans31, Peter J Halfmann38, David D Ho39, Michael R Holbrook40, Yaoxing Huang39, Sarah L James41, Lukasz Jaroszewski8, Trushar Jeevan28, Robert M Johnson4, Terry C Jones26,41, Astha Joshi17, Yoshihiro Kawaoka38,42,43, Lisa Kercher28, Marion P G Koopmans31, Bette Korber30, Eilay Koren22,44, Richard A Koup1,18, Eric B LeGresley41, Jacob E Lemieux45, Mariel J Liebeskind20, Zhuoming Liu15, Brandi Livingston28, James P Logue4, Yang Luo39, Adrian B McDermott1,18, Margaret J McElrath46, Victoria A Meliopoulos28, Vineet D Menachery47, David C Montefiori48, Barbara Mühlemann26,41, Vincent J Munster49, Jenny E Munt11, Manoj S Nair39, Antonia Netzl41, Anna M Niewiadomska50, Sijy O'Dell1,18, Andrew Pekosz51, Stanley Perlman52, Marjorie C Pontelli15, Barry Rockx31, Morgane Rolland24, Paul W Rothlauf15, Sinai Sacharen22,44, Richard H Scheuermann50, Stephen D Schmidt1,18, Michael Schotsaert21,35, Stacey Schultz-Cherry28, Robert A Seder1,18, Mayya Sedova8, Alessandro Sette7,53, Reed S Shabman1,2, Xiaoying Shen29, Pei-Yong Shi54, Maulik Shukla55,56, Viviana Simon21,32,33,35, Spencer Stumpf15, Nancy J Sullivan1,18, Larissa B Thackray17, James Theiler30, Paul G Thomas57, Sanja Trifkovic28, Sina Türeli41, Samuel A Turner41, Maria A Vakaki20, Harm van Bakel36, Laura A VanBlargan17, Leah R Vincent1,2, Zachary S Wallace50,58, Li Wang16, Maple Wang39, Pengfei Wang39, Wei Wang59, Scott C Weaver47, Richard J Webby28, Carol D Weiss59, David E Wentworth16, Stuart M Weston4, Sean P J Whelan15, Bradley M Whitener17, Samuel H Wilks41, Xuping Xie54, Baoling Ying17, Hyejin Yoon30, Bin Zhou16, Tomer Hertz60, Derek J Smith61, Michael S Diamond62,63,64,65, Diane J Post66,67, Mehul S Suthar68.
Abstract
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute of Allergy and Infectious Diseases within the National Institutes of Health established the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme. This effort was designed to provide a real-time risk assessment of SARS-CoV-2 variants that could potentially affect the transmission, virulence, and resistance to infection- and vaccine-induced immunity. The SAVE programme is a critical data-generating component of the US Government SARS-CoV-2 Interagency Group to assess implications of SARS-CoV-2 variants on diagnostics, vaccines and therapeutics, and for communicating public health risk. Here we describe the coordinated approach used to identify and curate data about emerging variants, their impact on immunity and effects on vaccine protection using animal models. We report the development of reagents, methodologies, models and notable findings facilitated by this collaborative approach and identify future challenges. This programme is a template for the response to rapidly evolving pathogens with pandemic potential by monitoring viral evolution in the human population to identify variants that could reduce the effectiveness of countermeasures.Entities:
Mesh：
Substances：
Year: 2022 PMID： 35361968 PMCID： PMC9345323 DOI： 10.1038/s41586-022-04690-5
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 69.504