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Literature DB >> 34664594

Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products.

Rebekah G Reynolds¹, Huong Quynh Anh Nguyen¹, Jordan C T Reddel¹, Regan J Thomson¹.

Abstract

Covering: 2000 to 2021Lignan natural products are found in many different plant species and possess numerous useful biological properties, such as anti-inflammatory, antiviral, antioxidant, antibacterial, and antitumor activities. Their utility in both traditional and conventional medicine, coupled with their structural diversity has made them popular synthetic targets over many decades. This review specifically addresses the cyclolignan subclass of the family, which possess both a C8-C8' and a C2-C7' linkage between two different phenylpropene units. We present a comprehensive overview of the diverse strategies employed by chemists to achieve enantioselective total syntheses of cyclolignans covering: 2000 to 2021.

Entities: Chemical

Mesh：

Substances：

Year: 2022 PMID： 34664594 PMCID： PMC8957534 DOI： 10.1039/d1np00057h

Source DB: PubMed Journal: Nat Prod Rep ISSN： 0265-0568 Impact factor: 13.423

76 in total

1. Asymmetric total synthesis of four bioactive lignans using donor-acceptor cyclopropanes and bioassay of (-)- and (+)-niranthin against hepatitis B and influenza viruses.

Authors: Ryotaro Ota; Daichi Karasawa; Mizuki Oshima; Koichi Watashi; Noriko Shimasaki; Yoshinori Nishii
Journal: RSC Adv Date: 2022-02-07 Impact factor: 3.361

1 in total

Recent strategies and tactics for the enantioselective total syntheses of cyclolignan natural products.

1. Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives.

2. TRIP-Catalyzed Asymmetric Synthesis of (+)-Yatein, (-)-α-Conidendrin, (+)-Isostegane, and (+)-Neoisostegane.

3. Aryltetralol and aryltetralone lignans from Holostylis reniformis.

4. Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.

5. Lignans from the Roots of Taxus wallichiana and Their α-Glucosidase Inhibitory Activities.

6. The intramolecular carboxyarylation approach to podophyllotoxin.

7. Enantioselective formal synthesis of (-)-podophyllotoxin from (2S,3R)-3-arylaziridine-2-carboxylate.

8. Discovery of podophyllotoxins.

Review 9. The clinical pharmacology of etoposide and teniposide.

10. Total synthesis of (+)-linoxepin by utilizing the Catellani reaction.

1. Asymmetric total synthesis of four bioactive lignans using donor-acceptor cyclopropanes and bioassay of (-)- and (+)-niranthin against hepatitis B and influenza viruses.