| Literature DB >> 14518993 |
Aaron J Reynolds1, Andrew J Scott, Craig I Turner, Michael S Sherburn.
Abstract
Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial production. Two are semisynthetic derivatives of podophyllotoxin. This paper describes concise, highly convergent, and conceptually novel approaches to (-)-podophyllotoxin and its enantiomer. These highly convergent syntheses feature a late-stage domino radical reaction to install the lactone ring and the pendant trimethoxyphenyl group.Entities:
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Year: 2003 PMID： 14518993 DOI： 10.1021/ja0376588
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419