Literature DB >> 34662188

Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy.

Sohail Rao1,2, Monica Betancourt-Garcia1, Yetunde O Kare-Opaneye1, Brett E Swierczewski3, Jason W Bennett3, Bri'Anna Horne4, Joseph Fackler4, Lia Patricia Suazo Hernandez1, Michael J Brownstein4.   

Abstract

Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This risk is heightened in patients who are on mechanical ventilation, are immunocompromised, and/or have chronic comorbidities. We report the case of a 52-year-old critically ill patient with a multidrug resistant Acinetobacter baumannii (MDR-A) respiratory infection who was successfully treated with antibiotics and intravenous and nebulized bacteriophage therapy.

Entities:  

Keywords:  Acinetobacter; Acinetobacter baumannii; bacteriophage; bacteriophage therapy; mechanical ventilation; multidrug resistance; multidrug-resistant bacterial infection

Mesh：

Substances：

Year:  2021        PMID： 34662188      PMCID： PMC8765271          DOI： 10.1128/AAC.00824-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  12 in total

1.  National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009.

Authors:  Jonathan R Edwards; Kelly D Peterson; Yi Mu; Shailendra Banerjee; Katherine Allen-Bridson; Gloria Morrell; Margaret A Dudeck; Daniel A Pollock; Teresa C Horan
Journal:  Am J Infect Control       Date:  2009-12       Impact factor: 2.918

2.  Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.

Authors:  Fernando Gordillo Altamirano; John H Forsyth; Ruzeen Patwa; Xenia Kostoulias; Michael Trim; Dinesh Subedi; Stuart K Archer; Faye C Morris; Cody Oliveira; Luisa Kielty; Denis Korneev; Moira K O'Bryan; Trevor J Lithgow; Anton Y Peleg; Jeremy J Barr
Journal:  Nat Microbiol       Date:  2021-01-11       Impact factor: 17.745

3.  Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection.

Authors:  Robert T Schooley; Biswajit Biswas; Jason J Gill; Adriana Hernandez-Morales; Jacob Lancaster; Lauren Lessor; Jeremy J Barr; Sharon L Reed; Forest Rohwer; Sean Benler; Anca M Segall; Randy Taplitz; Davey M Smith; Kim Kerr; Monika Kumaraswamy; Victor Nizet; Leo Lin; Melanie D McCauley; Steffanie A Strathdee; Constance A Benson; Robert K Pope; Brian M Leroux; Andrew C Picel; Alfred J Mateczun; Katherine E Cilwa; James M Regeimbal; Luis A Estrella; David M Wolfe; Matthew S Henry; Javier Quinones; Scott Salka; Kimberly A Bishop-Lilly; Ry Young; Theron Hamilton
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

Review 4.  Phage therapy for respiratory infections.

Authors:  Rachel Yoon Kyung Chang; Martin Wallin; Yu Lin; Sharon Sui Yee Leung; Hui Wang; Sandra Morales; Hak-Kim Chan
Journal:  Adv Drug Deliv Rev       Date:  2018-08-07       Impact factor: 15.470

Review 5.  Specific and Selective Bacteriophages in the Fight against Multidrug-resistant Acinetobacter baumannii.

Authors:  Natalia Bagińska; Anna Pichlak; Andrzej Górski; Ewa Jończyk-Matysiak
Journal:  Virol Sin       Date:  2019-05-15       Impact factor: 4.327

Review 6.  The prospect for bacteriophage therapy in Western medicine.

Authors:  Carl R Merril; Dean Scholl; Sankar L Adhya
Journal:  Nat Rev Drug Discov       Date:  2003-06       Impact factor: 84.694

7.  Development of a high throughput assay for indirectly measuring phage growth using the OmniLog(TM) system.

Authors:  Matthew Henry; Biswajit Biswas; Leah Vincent; Vishwesh Mokashi; Raymond Schuch; Kimberly A Bishop-Lilly; Shanmuga Sozhamannan
Journal:  Bacteriophage       Date:  2012-07-01

8.  Prognostic factors associated with mortality of drug-resistant Acinetobacter baumannii ventilator-associated pneumonia.

Authors:  Juthamas Inchai; Chaicharn Pothirat; Chaiwat Bumroongkit; Atikun Limsukon; Weerayut Khositsakulchai; Chalerm Liwsrisakun
Journal:  J Intensive Care       Date:  2015-03-02

Review 9.  Bacteriophage Therapy of Bacterial Infections: The Rediscovered Frontier.

Authors:  Nejat Düzgüneş; Melike Sessevmez; Metin Yildirim
Journal:  Pharmaceuticals (Basel)       Date:  2021-01-05

10.  Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection.

Authors:  James B Doub; Vincent Y Ng; Aaron J Johnson; Magdalena Slomka; Joseph Fackler; Bri'Anna Horne; Michael J Brownstein; Matthew Henry; Francisco Malagon; Biswajit Biswas
Journal:  Antibiotics (Basel)       Date:  2020-05-09
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  4 in total

1.  inPhocus: Current State and Challenges of Phage Research in Singapore.

Authors:  Navin Kumar Verma; Si Jia Tan; John Chen; Hanrong Chen; Muhammad Hafiz Ismail; Scott A Rice; Pablo Bifani; Sukumar Hariharan; Vivek Daniel Paul; Bharathi Sriram; Linh Chi Dam; Chia Ching Chan; Peiying Ho; Boon Chong Goh; Shimin Jasmine Chung; Kenneth Choon Meng Goh; Shu Hua Thong; Andrea Lay-Hoon Kwa; Adam Ostrowski; Thet Tun Aung; Halimah Razali; Shermaine W Y Low; Mani Shankar Bhattacharyya; Hemant K Gautam; Rajamani Lakshminarayanan; Thomas Sicheritz-Pontén; Martha R J Clokie; Wilfried Moreira; Maurice Adrianus Monique van Steensel
Journal:  Phage (New Rochelle)       Date:  2022-03-18

2.  Case Commentary: Novel Therapy for Multidrug-Resistant Acinetobacter baumannii Infection.

Authors:  Brianna M Eales; Vincent H Tam
Journal:  Antimicrob Agents Chemother       Date:  2021-10-25       Impact factor: 5.938

Review 3.  Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far.

Authors:  Marzanna Łusiak-Szelachowska; Ryszard Międzybrodzki; Zuzanna Drulis-Kawa; Kathryn Cater; Petar Knežević; Cyprian Winogradow; Karolina Amaro; Ewa Jończyk-Matysiak; Beata Weber-Dąbrowska; Justyna Rękas; Andrzej Górski
Journal:  J Biomed Sci       Date:  2022-03-30       Impact factor: 8.410

4.  Whole-Genome Sequencing of ST2 A. baumannii Causing Bloodstream Infections in COVID-19 Patients.

Authors:  Sabrina Cherubini; Mariagrazia Perilli; Bernardetta Segatore; Paolo Fazii; Giustino Parruti; Antonella Frattari; Gianfranco Amicosante; Alessandra Piccirilli
Journal:  Antibiotics (Basel)       Date:  2022-07-15
  4 in total

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