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Literature DB >> 346610

Significance of alpha-subunit HCG demonstrated in breast carcinomas by the immunoperoxidase technique.

Abstract

Fifty-three breast carcinomas were examined by an indirect immunoperoxidase technique for the presence of the alpha-subunit of human chorionic gonadotrophin. Positive staining occurred in 12 (22.6%). There was no correlation between alpha-subunit production and specific histological features, but production was related to the presence of lymph node metastases and hence a poorer prognosis. The alpha-subunit could be used as a prognostic indicator in the assessment of breast carcinoma.

Entities: Disease Species

Mesh：

Substances：
Chorionic Gonadotropin

Year: 1978 PMID： 346610 PMCID： PMC1145237 DOI： 10.1136/jcp.31.3.245

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

13 in total

1. The clinical application of a specific radioimmunoassay for human chorionic gondotropin in trophoblastic and nontrophoblastic tumors.

Authors: D P Goldstein; T S Kosasa; A T Skarim
Journal: Surg Gynecol Obstet Date: 1974-05

2. Ectopic production of human chorionic somatomammotropin by nontrophoblastic cancers.

Authors: B D Weintraub; S W Rosen
Journal: J Clin Endocrinol Metab Date: 1971-01 Impact factor: 5.958

3. Effect of human chorionic somatomammotrophin and human chorionic gonadotrophin on phytohaemagglutinin-induced lymphocyte transformation.

Authors: S F Contractor; H Davies
Journal: Nat New Biol Date: 1973-06-27

4. Subunits of human chorionic gonadotropin: unbalanced synthesis and secretion by clonal cell strains derived from a bronchogenic carcinoma.

Authors: A H Tashjian; B D Weintraub; N J Barowsky; A S Rabson; S W Rosen
Journal: Proc Natl Acad Sci U S A Date: 1973-05 Impact factor: 11.205

5. Ectopic production of the isolated alpha subunit of the glycoprotein hormones. A quantitative marker in certain cases of cancer.

Authors: S W Rosen; B D Weintraub
Journal: N Engl J Med Date: 1974-06-27 Impact factor: 91.245

6. Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material.

Authors: J Burns
Journal: Histochemistry Date: 1975-06-05

7. Immunoglobulin-containing cells in human tonsils as demonstrated by immunohistochemistry.

Authors: R C Curran; E L Jones
Journal: Clin Exp Immunol Date: 1977-04 Impact factor: 4.330

8. Prognostic significance of inappropriate production of pregnancy proteins by breast cancers.

Authors: C H Horne; I N Reid; G D Milne
Journal: Lancet Date: 1976-08-07 Impact factor: 79.321

9. Response of lymphocytes from cancer patients to human chorionic gonadotrophin.

Authors: M Wass; G A Rawlins; C R Pentycross; K D Bagshawe
Journal: Lancet Date: 1977-01-22 Impact factor: 79.321

10. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.

Authors: H J BLOOM; W W RICHARDSON
Journal: Br J Cancer Date: 1957-09 Impact factor: 7.640

8 in total

1. Immunocytochemical detection of tumour markers in bone metastases from carcinoma of the breast.

Authors: P Gugliotta; G Botta; G Bussolati
Journal: Histochem J Date: 1981-11

2. Demonstration of carcinoembryonic antigen in human breast carcinomas by the immunoperoxidase technique.

Authors: R A Walker
Journal: J Clin Pathol Date: 1980-04 Impact factor: 3.411

3. Transferrin receptor (TrfR) expression in breast carcinoma and its possible relationship to prognosis. An immunohistochemical study.

Authors: F Wrba; E Ritzinger; A Reiner; J H Holzner
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1986