Literature DB >> 4514312

Subunits of human chorionic gonadotropin: unbalanced synthesis and secretion by clonal cell strains derived from a bronchogenic carcinoma.

A H Tashjian, B D Weintraub, N J Barowsky, A S Rabson, S W Rosen.   

Abstract

Three clones of ectopic hormone-producing cells from a single human neoplasm (bronchogenic carcinoma) show different rates of synthesis and secretion of chorionic gonadotropin and its alpha and beta subunits. For each clone, the amount of one or the other subunit always exceeded that of the complete hormone molecule. These findings may be analogous to unbalanced immunoglobulin chain synthesis in certain forms of myeloma.

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Year:  1973        PMID： 4514312      PMCID： PMC433510          DOI： 10.1073/pnas.70.5.1419

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Differences between ectopic MSH and pituitary MSH.

Authors:  M Shapiro; W E Nicholson; D N Orth; W M Mitchell; G W Liddle
Journal:  J Clin Endocrinol Metab       Date:  1971-09       Impact factor: 5.958

Review 2.  Clinical and laboratory studies of ectopic humoral syndromes.

Authors:  G W Liddle; W E Nicholson; D P Island; D N Orth; K Abe; S C Lowder
Journal:  Recent Prog Horm Res       Date:  1969

3.  Humoral syndromes associated with cancer.

Authors:  M B Lipsett
Journal:  Cancer Res       Date:  1965-08       Impact factor: 12.701

4.  Monotropic increase of serum FSH correlated with low sperm count in young men with idiopathic oligospermia and aspermia.

Authors:  S W Rosen; B D Weintraub
Journal:  J Clin Endocrinol Metab       Date:  1971-03       Impact factor: 5.958

5.  Chromosomal analysis, organ-specific function and appearance of six clonal strains of rat pituitary tumor cells.

Authors:  C Sonnenschein; U I Richardson; A H Tashjian
Journal:  Exp Cell Res       Date:  1970-07       Impact factor: 3.905

6.  Some thoughts on the nature of ectopic parathyroid hormones.

Authors:  B S Roof; B Carpenter; D J Fink; G S Gordan
Journal:  Am J Med       Date:  1971-05       Impact factor: 4.965

Review 7.  Proinsulin and the biosynthesis of insulin.

Authors:  D F Steiner; J L Clark; C Nolan; A H Rubenstein; E Margoliash; B Aten; P E Oyer
Journal:  Recent Prog Horm Res       Date:  1969

8.  Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer.

Authors:  B L Riggs; C D Arnaud; J C Reynolds; L H Smith
Journal:  J Clin Invest       Date:  1971-10       Impact factor: 14.808

9.  Control of growth hormone production by a clonal strain of rat pituitary cells. Stimulation by hydrocortisone.

Authors:  F C Bancroft; L Levine; A H Tashjian
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539

10.  Establishment of a clonal strain of hepatoma cells which secrete albumin.

Authors:  U I Richardson; A H Tashjian; L Levine
Journal:  J Cell Biol       Date:  1969-01       Impact factor: 10.539
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  23 in total

1.  Synthesis of alpha subunit of human chorionic gonadotrophin by presumptive HeLa cells.

Authors:  J Y Chou; B D Weintraub; S W Rosen; J Whangpeng; H D Sussman; J R Haughom; J C Robinson
Journal:  In Vitro       Date:  1976-08

2.  Regulation of alkaline phosphatase expression in human choriocarcinoma cell lines.

Authors:  T A Hamilton; A W Tin; H H Sussman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

3.  Establishment of clonal human placental cells synthesizing human choriogonadotropin.

Authors:  J Y Chou
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Secretion of hypothalamic and pituitary hormones by non-endocrine tumours.

Authors:  T J Martin
Journal:  J Clin Pathol Suppl (Assoc Clin Pathol)       Date:  1976

Review 5.  Cell differentiation and the biological significance of inappropriate tumour products.

Authors:  M L Ellison
Journal:  Proc R Soc Med       Date:  1977-12

6.  Human chorionic gonadotropin in gastric carcinoma. An immunohistochemical study suggesting independent regulation of subunits.

Authors:  M Fukayama; Y Hayashi; M Koike
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987

7.  Synthesis and processing of human chorionic gonadotropin subunits in cultured choriocarcinoma cells.

Authors:  R W Ruddon; C A Hanson; N J Addison
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

8.  Identification of separate mRNAs coding for the alpha and beta subunits of thyrotropin.

Authors:  N C Vamvakopoulos; I A Kourides
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

9.  Ectopic production of the isolated beta subunit of human chorionic gonadotropin.

Authors:  B D Weintraub; S W Rosen
Journal:  J Clin Invest       Date:  1973-12       Impact factor: 14.808

10.  Significance of alpha-subunit HCG demonstrated in breast carcinomas by the immunoperoxidase technique.

Authors:  R A Walker
Journal:  J Clin Pathol       Date:  1978-03       Impact factor: 3.411
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