Masateru Kawakubo1, Michinobu Nagao2, Noriko Kikuchi3, Atsushi Yamamoto4, Risako Nakao3, Yuka Matsuo4, Koichiro Kaneko4, Eri Watanabe3, Masayuki Sasaki1, Shinichi Nunoda5, Shuji Sakai4. 1. Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. 2. Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. nagao.michinobu@twmu.ac.jp. 3. Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan. 4. Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. 5. Department of Therapeutic Strategy for Severe Heart Failure, Graduate School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Abstract
OBJECTIVE: Heart transplant rejection leads to cardiac allograft vasculopathy (CAV). 13N-ammonia positron emission tomography (PET) can be useful in detecting CAV, as it can evaluate both epicardial vessels and microvasculature. In this study, we evaluated the regional wall motion in heart transplant patients using our PET-specific feature-tracking (FT) algorithm for myocardial strain calculation and validated it using a cardiovascular magnetic resonance (CMR) FT strain as a reference. METHODS: A total of 15 heart transplant patients who underwent both 13N-ammonia PET and CMR within 3 months were retrospectively enrolled. The same slice position of short-axis cine images of the middle slice of left ventricle (LV) and the same slice position of horizontal long-axis cine images were selected for the two modalities to measure the circumferential strain (CS) and longitudinal strain (LS), respectively. Based on the FT technique, time-strain curves were calculated by semi-automatic tracking of the endocardial contour on cine images throughout a cardiac cycle. The peak value in the time-strain curve was defined as the representative value. Correlations of CS and LS between PET and CMR were analyzed using Pearson correlation coefficients. The inter-modality error of strain measurements was evaluated using intraclass correlation coefficients (ICCs) with two-way random single measures. RESULTS: Excellent correlations of CS and LS between PET and CMR were observed (CS: r = 0.80; p < 0.01; LS: r = 0.87; p < 0.01). Excellent ICCs were observed (0.89 and 0.85) in CS and LS derived from PET. CONCLUSIONS: We propose the first PET strain showing an excellent agreement with the CMR strain and high reproducibility in measurement.
OBJECTIVE: Heart transplant rejection leads to cardiac allograft vasculopathy (CAV). 13N-ammonia positron emission tomography (PET) can be useful in detecting CAV, as it can evaluate both epicardial vessels and microvasculature. In this study, we evaluated the regional wall motion in heart transplant patients using our PET-specific feature-tracking (FT) algorithm for myocardial strain calculation and validated it using a cardiovascular magnetic resonance (CMR) FT strain as a reference. METHODS: A total of 15 heart transplant patients who underwent both 13N-ammonia PET and CMR within 3 months were retrospectively enrolled. The same slice position of short-axis cine images of the middle slice of left ventricle (LV) and the same slice position of horizontal long-axis cine images were selected for the two modalities to measure the circumferential strain (CS) and longitudinal strain (LS), respectively. Based on the FT technique, time-strain curves were calculated by semi-automatic tracking of the endocardial contour on cine images throughout a cardiac cycle. The peak value in the time-strain curve was defined as the representative value. Correlations of CS and LS between PET and CMR were analyzed using Pearson correlation coefficients. The inter-modality error of strain measurements was evaluated using intraclass correlation coefficients (ICCs) with two-way random single measures. RESULTS: Excellent correlations of CS and LS between PET and CMR were observed (CS: r = 0.80; p < 0.01; LS: r = 0.87; p < 0.01). Excellent ICCs were observed (0.89 and 0.85) in CS and LS derived from PET. CONCLUSIONS: We propose the first PET strain showing an excellent agreement with the CMR strain and high reproducibility in measurement.
Authors: Marshall I Hertz; David O Taylor; Elbert P Trulock; Mark M Boucek; Paul J Mohacsi; Leah B Edwards; Berkeley M Keck Journal: J Heart Lung Transplant Date: 2002-09 Impact factor: 10.247
Authors: Paco E Bravo; Brian A Bergmark; Tomas Vita; Viviany R Taqueti; Ankur Gupta; Sara Seidelmann; Thomas E Christensen; Michael T Osborne; Nishant R Shah; Nina Ghosh; Jon Hainer; Courtney F Bibbo; Meagan Harrington; Fred Costantino; Mandeep R Mehra; Sharmila Dorbala; Ron Blankstein; Akshay Desai; Lynne Stevenson; Michael M Givertz; Marcelo F Di Carli Journal: Eur Heart J Date: 2018-01-21 Impact factor: 29.983
Authors: C H Spes; H Mudra; S D Schnaack; V Klauss; F M Reichle; P Uberfuhr; K Theisen; C E Angermann Journal: Am J Cardiol Date: 1996-07-15 Impact factor: 2.778