Literature DB >> 34618261

Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV.

V I Dubrovina1, T P Starovoitova2, O V Yur'eva2, A B Pyatidesyatnikova2, V A Potapov3, M V Musalov3, S V Balakhonov2.   

Abstract

We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with Yersinia pestis EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Yersinia pestis EV; immunopoiesis; organoselenium; selenium

Mesh：

Substances：

Year:  2021        PMID： 34618261     DOI： 10.1007/s10517-021-05287-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Oral administration of synthetic selenium nanoparticles induced robust Th1 cytokine pattern after HBs antigen vaccination in mouse model.

Authors:  Mehdi Mahdavi; Faranak Mavandadnejad; Mohammad H Yazdi; Elnaz Faghfuri; Hura Hashemi; Somayeh Homayouni-Oreh; Ramin Farhoudi; Ahmad R Shahverdi
Journal:  J Infect Public Health       Date:  2016-03-23       Impact factor: 3.718

2.  Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound.

Authors:  O V Yur'eva; V I Dubrovina; V A Potapov; M V Musalov; T P Starovoitova; T A Ivanova; T T Shkaruba; V A Yakimov; S V Balakhonov
Journal:  Bull Exp Biol Med       Date:  2020-06-02       Impact factor: 0.804

3.  Effect of Synthetic Organoselenium Drug on the Degree of Pathological Changes in the Organs of White Mice Immunized with Tularemia and Brucellosis Vaccines.

Authors:  O V Yurieva; V I Dubrovina; V A Potapov; M V Musalov; T P Starovoitova; T A Ivanova; A V Gromova; T T Shkaruba; S V Balakhonov
Journal:  Bull Exp Biol Med       Date:  2019-11-21       Impact factor: 0.804
  3 in total

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