Literature DB >> 32488779

Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound.

O V Yur'eva1, V I Dubrovina2, V A Potapov3, M V Musalov3, T P Starovoitova1, T A Ivanova1, T T Shkaruba1, V A Yakimov3, S V Balakhonov1.   

Abstract

We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The experimental preparation reduced the cAMP/cGMP ratio, which indicated an increase in proliferative activity of cells of immunocompetent organs (thymus and spleen) in experimental animals. It was shown that 974zh intensified the immune response to Yersinia pestis EV thereby increasing the resistance to the plague agent.

Entities:  

Keywords:  Yersinia pestis EV; cAMP; cGMP; immunity; selenium-organic preparation

Mesh：

Substances：

Year:  2020        PMID： 32488779     DOI： 10.1007/s10517-020-04819-4

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

Review 1.  Relationship Between Selenium in Human Tissues and Breast Cancer: a Meta-analysis Based on Case-Control Studies.

Authors:  Xiaopan Zhu; Da Pan; Niannian Wang; Shaokang Wang; Guiju Sun
Journal:  Biol Trace Elem Res       Date:  2021-01-08       Impact factor: 3.738

2.  Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV.

Authors:  V I Dubrovina; T P Starovoitova; O V Yur'eva; A B Pyatidesyatnikova; V A Potapov; M V Musalov; S V Balakhonov
Journal:  Bull Exp Biol Med       Date:  2021-10-07       Impact factor: 0.804
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.