Literature DB >> 34609642

Breast reconstruction is a viable option for older patients.

Utku C Dolen1, Jody Law1, Marissa M Tenenbaum1, Terence M Myckatyn2,3.   

Abstract

PURPOSE: Breast cancer is diagnosed at a median age of 62 years in the USA. At the same time, mortality rates for breast cancer continue to decrease, falling by 40% from 1989 to 2016. In the coming decades, the number of elderly patients with breast cancer, potentially seeking reconstruction, is expected to increase.
METHODS: A retrospective chart review of 309 patients, aged 60 years or older, undergoing immediate or delayed breast reconstruction, was conducted. Patient characteristics, clinical information and major complications requiring reoperation were evaluated. Multivariate analyses identified factors contributing to complications such as BMI, comorbidities, smoking status, history of previous breast conservation therapy (BCT), total expander volume, radiotherapy, and chemotherapy.
RESULTS: 26.7% of patients had at least one complication requiring reoperation, and 6.9% of patients suffered reconstructive failure. Logistic regression analysis of all patients (n = 309) found a statistically significant relationship between major complication and history of ipsilateral BCT (p = 0.026) and adjuvant chemotherapy (p = 0.005). Logistic regression analysis in patients undergoing tissue expander (TE) reconstruction (n = 215) showed that major complications were related to BMI over 35 kg/m2 (p = 0.04), history of ipsilateral BCT (p = 0.048), and adjuvant chemotherapy (p = 0.033).
CONCLUSION: Breast reconstruction in women over 60 years old was not independently associated with higher major complication rates in our series.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Breast reconstruction; Complication; Elderly; Flap; Implant; Lumpectomy; Mastectomy; Tissue expander

Mesh:

Year:  2021        PMID: 34609642     DOI: 10.1007/s10549-021-06389-z

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN: 0167-6806            Impact factor:   4.872


  14 in total

1.  Surgical outcomes in women ≥70 years undergoing mastectomy with and without reconstruction for breast cancer.

Authors:  Simone Mays; Hanan Alabdulkareem; Paul Christos; Rache Simmons; Tracy-Ann Moo
Journal:  Am J Surg       Date:  2017-04-05       Impact factor: 2.565

2.  Is immediate breast reconstruction safe in women over 70? An analysis of the National Surgical Quality Improvement Program (NSQIP) database.

Authors:  Fernando A Angarita; Fahima Dossa; Jesse Zuckerman; David R McCready; Tulin D Cil
Journal:  Breast Cancer Res Treat       Date:  2019-06-01       Impact factor: 4.872

3.  Impact of Neoadjuvant and Adjuvant Chemotherapy on Immediate Tissue Expander Breast Reconstruction.

Authors:  Utku C Dolen; Alexandra C Schmidt; Grace T Um; Ketan Sharma; Michael Naughton; Imran Zoberi; Julie M Margenthaler; Terence M Myckatyn
Journal:  Ann Surg Oncol       Date:  2016-03-04       Impact factor: 5.344

Review 4.  Breast reconstruction in elderly women breast cancer: a review.

Authors:  Lauren Walton; Koshy Ommen; Riccardo A Audisio
Journal:  Cancer Treat Rev       Date:  2011-03-02       Impact factor: 12.111

Review 5.  Patterns and outcomes of breast reconstruction in older women - A systematic review of the literature.

Authors:  D D Oh; K Flitcroft; M E Brennan; A J Spillane
Journal:  Eur J Surg Oncol       Date:  2016-02-18       Impact factor: 4.424

6.  Mastectomy and Immediate Breast Reconstruction for Cancer in the Elderly: A National Cancer Data Base Study.

Authors:  Waleed O Gibreel; Courtney N Day; Tanya L Hoskin; Judy C Boughey; Elizabeth B Habermann; Tina J Hieken
Journal:  J Am Coll Surg       Date:  2017-02-23       Impact factor: 6.113

7.  Pre-operative assessment of cancer in the elderly (PACE): a comprehensive assessment of underlying characteristics of elderly cancer patients prior to elective surgery.

Authors:  D Pope; H Ramesh; R Gennari; G Corsini; M Maffezzini; H J Hoekstra; D Mobarak; K Sunouchi; A Stotter; C West; R A Audisio
Journal:  Surg Oncol       Date:  2006-12       Impact factor: 3.279

8.  Variation in the utilization of reconstruction following mastectomy in elderly women.

Authors:  Haejin In; Wei Jiang; Stuart R Lipsitz; Bridget A Neville; Jane C Weeks; Caprice C Greenberg
Journal:  Ann Surg Oncol       Date:  2012-12-22       Impact factor: 5.344

9.  Midlife reactions to mastectomy and subsequent breast reconstruction.

Authors:  M K Goin; J M Goin
Journal:  Arch Gen Psychiatry       Date:  1981-02

10.  The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study.

Authors:  Rachel L O'Connell; Tim Rattay; Rajiv V Dave; Adam Trickey; Joanna Skillman; Nicola L P Barnes; Matthew Gardiner; Adrian Harnett; Shelley Potter; Chris Holcombe
Journal:  Br J Cancer       Date:  2019-03-29       Impact factor: 7.640

View more
  1 in total

1.  Age and Breast Reconstruction.

Authors:  Luis Chang-Azancot; Pedro Abizanda; María Gijón; Nitzan Kenig; Manuel Campello; Jessica Juez; Antonio Talaya; Gregorio Gómez-Bajo; Javier Montón; Rodrigo Sánchez-Bayona
Journal:  Aesthetic Plast Surg       Date:  2022-08-04       Impact factor: 2.708

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.