Literature DB >> 3460083

Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site.

J Sample, M Hummel, D Braun, M Birkenbach, E Kieff.   

Abstract

Three cDNA clones of the second Epstein-Barr virus nuclear antigen (EBNA2) mRNA and two of the EBNA1 mRNA were analyzed. Two EBNA2 clones begin 42 bases 3' to a promoter in the Epstein-Barr virus long internal repeat, which is likely to be the EBNA2 promoter. Surprisingly, the first splice creates an AUG at the beginning of the first of two nonoverlapping open reading frames. The second open reading frame encodes EBNA2. Two incomplete EBNA1 mRNA cDNA clones begin with parts of two of the EBNA2 exons and contain two other exons that map 19 and 59 kilobases 3' to the EBNA2 coding domain. The 3' exon of this mRNA encodes EBNA1. A model for regulation of transcription of these RNAs is presented.

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Year:  1986        PMID： 3460083      PMCID： PMC323897          DOI： 10.1073/pnas.83.14.5096

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  54 in total

1.  An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells.

Authors:  D Wang; D Liebowitz; E Kieff
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

2.  High-frequency establishment of human immunoglobulin-producing lymphoblastoid lines from normal and malignant lymphoid tissue and peripheral blood.

Authors:  K Nilsson
Journal:  Int J Cancer       Date:  1971-11-15       Impact factor: 7.396

3.  RNA encoded by the IR1-U2 region of Epstein-Barr virus DNA in latently infected, growth-transformed cells.

Authors:  V van Santen; A Cheung; M Hummel; E Kieff
Journal:  J Virol       Date:  1983-05       Impact factor: 5.103

4.  The roles of individual polyoma virus early proteins in oncogenic transformation.

Authors:  M Rassoulzadegan; A Cowie; A Carr; N Glaichenhaus; R Kamen; F Cuzin
Journal:  Nature       Date:  1982-12-23       Impact factor: 49.962

5.  Characterization of the major Epstein-Barr virus-specific RNA in Burkitt lymphoma-derived cells.

Authors:  J R Arrand; L Rymo
Journal:  J Virol       Date:  1982-02       Impact factor: 5.103

6.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

7.  Identification of Epstein-Barr nuclear antigen polypeptide in mouse and monkey cells after gene transfer with a cloned 2.9-kilobase-pair subfragment of the genome.

Authors:  D K Fischer; M F Robert; D Shedd; W P Summers; J E Robinson; J Wolak; J E Stefano; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

8.  Epstein-Barr virus DNA XII. A variable region of the Epstein-Barr virus genome is included in the P3HR-1 deletion.

Authors:  W King; T Dambaugh; M Heller; J Dowling; E Kieff
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

9.  DNA of Epstein-Barr virus VIII: B95-8, the previous prototype, is an unusual deletion derivative.

Authors:  N Raab-Traub; T Dambaugh; E Kieff
Journal:  Cell       Date:  1980-11       Impact factor: 41.582

10.  Spliced RNA from the IR1-U2 region of Epstein-Barr virus: presence of an open reading frame for a repetitive polypeptide.

Authors:  M Bodescot; B Chambraud; P Farrell; M Perricaudet
Journal:  EMBO J       Date:  1984-08       Impact factor: 11.598
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  123 in total

1.  Functional analysis of the CD4(+) T-cell response to Epstein-Barr virus: T-cell-mediated activation of resting B cells and induction of viral BZLF1 expression.

Authors:  Z Fu; M J Cannon
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

2.  Conserved regions in the Epstein-Barr virus leader protein define distinct domains required for nuclear localization and transcriptional cooperation with EBNA2.

Authors:  R Peng; J Tan; P D Ling
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

3.  Interaction of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) with HS1-associated protein X-1: implication of cytoplasmic function of EBNA-LP.

Authors:  Y Kawaguchi; K Nakajima; M Igarashi; T Morita; M Tanaka; M Suzuki; A Yokoyama; G Matsuda; K Kato; M Kanamori; K Hirai
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

4.  The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated.

Authors:  J Sample; E B Henson; C Sample
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

5.  Sequence and functional analysis of EBNA-LP and EBNA2 proteins from nonhuman primate lymphocryptoviruses.

Authors:  R Peng; A V Gordadze; E M Fuentes Pananá; F Wang; J Zong; G S Hayward; J Tan; P D Ling
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

6.  Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell lines.

Authors:  J Finke; M Rowe; B Kallin; I Ernberg; A Rosén; J Dillner; G Klein
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

7.  BamHI E region of the Epstein-Barr virus genome encodes three transformation-associated nuclear proteins.

Authors:  A Ricksten; B Kallin; H Alexander; J Dillner; R Fåhraeus; G Klein; R Lerner; L Rymo
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

8.  The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.

Authors:  D M Walling; A G Perkins; J Webster-Cyriaque; L Resnick; N Raab-Traub
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  cDNA cloning of ECP40, an embryogenic-cell protein in carrot, and its expression during somatic and zygotic embryogenesis.

Authors:  T Kiyosue; K Yamaguchi-Shinozaki; K Shinozaki; H Kamada; H Harada
Journal:  Plant Mol Biol       Date:  1993-03       Impact factor: 4.076

10.  Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.

Authors:  F Wang; S F Tsang; M G Kurilla; J I Cohen; E Kieff
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103
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