Literature DB >> 3460078

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

V R Sara, C Carlsson-Skwirut, C Andersson, E Hall, B Sjögren, A Holmgren, H Jörnvall.   

Abstract

A fetal form of somatomedin (insulin-like growth factor) that crossreacts in the fetal brain radioreceptor assay has been proposed to exist in humans. Using this assay to monitor activity during purification, we have isolated a variant form of insulin-like growth factor I (IGF-I) from human fetal brain tissue. The variant IGF-I showed potent crossreaction in the fetal brain radioreceptor assay and stimulated DNA synthesis in fetal brain cells in vitro. Structural analysis revealed the variant IGF-I to have a truncated NH2-terminal region compared to IGF-I isolated from serum. An additional peptide, which displayed less potent crossreaction in the fetal brain radioreceptor assay, was also isolated from the human fetal brain. Partial amino acid sequence analysis revealed identity to insulin-like growth factor II.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3460078      PMCID： PMC323852          DOI： 10.1073/pnas.83.13.4904

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  A new spectrophotometric assay for protein in cell extracts.

Authors:  V F Kalb; R W Bernlohr
Journal:  Anal Biochem       Date:  1977-10       Impact factor: 3.365

2.  Immunoreactive somatomedin A in human serum.

Authors:  K Hall; J Brandt; G Enberg; L Fryklund
Journal:  J Clin Endocrinol Metab       Date:  1979-02       Impact factor: 5.958

3.  The influence of purified somatomedins and insulin on foetal rat brain DNA synthesis in vitro.

Authors:  G Enberg; A Tham; V R Sara
Journal:  Acta Physiol Scand       Date:  1985-10

Review 4.  Growth and somatomedins.

Authors:  K Hall; V R Sara
Journal:  Vitam Horm       Date:  1983       Impact factor: 3.421

Review 5.  Somatomedins and the fetus.

Authors:  V R Sara; K Hall
Journal:  Clin Obstet Gynecol       Date:  1980-09       Impact factor: 2.190

6.  Primary structure of human insulin-like growth factor II.

Authors:  E Rinderknecht; R E Humbel
Journal:  FEBS Lett       Date:  1978-05-15       Impact factor: 4.124

7.  Human embryonic somatomedin.

Authors:  V R Sara; K Hall; C H Rodeck; L Wetterberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

8.  Sequence of cDNA encoding human insulin-like growth factor I precursor.

Authors:  M Jansen; F M van Schaik; A T Ricker; B Bullock; D E Woods; K H Gabbay; A L Nussbaum; J S Sussenbach; J L Van den Brande
Journal:  Nature       Date:  1983 Dec 8-14       Impact factor: 49.962

9.  Ontogenesis of somatomedin and insulin receptors in the human fetus.

Authors:  V R Sara; K Hall; M Misaki; L Fryklund; N Christensen; L Wetterberg
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

10.  Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins.

Authors:  M E Svoboda; J J Van Wyk; D G Klapper; R E Fellows; F E Grissom; R J Schlueter
Journal:  Biochemistry       Date:  1980-02-19       Impact factor: 3.162
View more
  26 in total

1.  Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue.

Authors:  E Y Adashi; C E Resnick; E Ricciarelli; A Hurwitz; E Kokia; C Tedeschi; L Botero; E R Hernandez; R G Rosenfeld; C Carlsson-Skwirut
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

Review 2.  Neurodevelopmental effects of insulin-like growth factor signaling.

Authors:  John O'Kusky; Ping Ye
Journal:  Front Neuroendocrinol       Date:  2012-06-16       Impact factor: 8.606

Review 3.  Molecular biology of the insulin-like growth factors. Relevance to nervous system function.

Authors:  J E Hepler; P K Lund
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

Review 4.  The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system.

Authors:  F Folli; S Ghidella; L Bonfanti; C R Kahn; A Merighi
Journal:  Mol Neurobiol       Date:  1996-10       Impact factor: 5.590

5.  Spatiotemporal Regulation of Insulin-Like Growth Factor-1 and Its Receptor in the Brain: Is There a Role for Growth Hormone?

Authors:  Sarah M Gray; Michael O Thorner
Journal:  Endocrinology       Date:  2017-02-01       Impact factor: 4.736

6.  Secretion of polypeptides related to epidermal growth factor and insulinlike growth factor I by a human teratocarcinoma cell line.

Authors:  N H Jing; R Shiurba; H Kitani; H Kawakatsu; Y Tomooka; T Sakakura
Journal:  In Vitro Cell Dev Biol       Date:  1991-11

7.  Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.

Authors:  T Niikura; Y Hashimoto; T Okamoto; Y Abe; T Yasukawa; M Kawasumi; T Hiraki; Y Kita; K Terashita; K Kouyama; I Nishimoto
Journal:  J Neurosci       Date:  2001-03-15       Impact factor: 6.167

Review 8.  Insulin and insulin-like growth factor receptors in the nervous system.

Authors:  M Adamo; M K Raizada; D LeRoith
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

9.  Insulin-like growth factor (IGF)-I, -II and IGF-binding proteins in the cyst fluid of a patient with astrocytoma.

Authors:  W Zumkeller; M Sääf; T Rähn
Journal:  Childs Nerv Syst       Date:  1993-04       Impact factor: 1.475

10.  An evaluation of different enzymatic cleavage methods for recombinant fusion proteins, applied on des(1-3)insulin-like growth factor I.

Authors:  G Forsberg; B Baastrup; H Rondahl; E Holmgren; G Pohl; M Hartmanis; M Lake
Journal:  J Protein Chem       Date:  1992-04
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.