Literature DB >> 6942423

Human embryonic somatomedin.

V R Sara, K Hall, C H Rodeck, L Wetterberg.   

Abstract

A radioreceptor assay utilizing human fetal brain plasma membrane as matrix and somatomedin A as ligand (fetal brain RRA-SMA) was developed. Increased levels of fetal brain RRA-SMA were found in the fetal circulation. The concentration was approximately 4-fold higher in the fetal as compared to the adult human. At birth, values fell within the adult range. In contrast, adult somatomedins determined by somatomedin radioimmunoassay were undetectable in the fetus and below the adult range at birth. Levels of fetal brain RRA-SMA were decreased in fetuses with different clinical disorders. In healthy newborns at cesarean section a significant correlation between serum fetal brain RRA-SMA values and birth weight and length was found. These results indicate the presence of an embryonic somatomedin in humans. The fetal brain RRA-SMA may provide a reliable index of fetal growth.

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Year:  1981        PMID： 6942423      PMCID： PMC319523          DOI： 10.1073/pnas.78.5.3175

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay.

Authors:  R W Furlanetto; L E Underwood; J J Van Wyk; A J D'Ercole
Journal:  J Clin Invest       Date:  1977-09       Impact factor: 14.808

2.  Multiple forms of thymidine kinase during human development.

Authors:  B Bernard; B Preston; P Beaupre; K Elliott; D Sadava
Journal:  Biol Neonate       Date:  1977

3.  Somatomedin A in human serum, determined by radioreceptor assay.

Authors:  K Takano; K Hall; M Ritzén; L Iselius; H Sievertsson
Journal:  Acta Endocrinol (Copenh)       Date:  1976-07

Review 4.  Hormonal regulation of growth by somatomedin and other tissue growth factors.

Authors:  W H Daughaday
Journal:  Clin Endocrinol Metab       Date:  1977-03

5.  Characterization of the insulin and somatomedin-C receptors in human placental cell membranes.

Authors:  R N Marshall; L E Underwood; S J Voina; D B Foushee; J J Van Wyk
Journal:  J Clin Endocrinol Metab       Date:  1974-08       Impact factor: 5.958

6.  Radioreceptor assay for somatomedin A.

Authors:  K Hall; K Takano; L Fryklund
Journal:  J Clin Endocrinol Metab       Date:  1974-11       Impact factor: 5.958

7.  Purified human somatomedin A and rat multiplication stimulating activity. Mitogens for cultured fibroblasts that cross-react with the same growth peptide receptors.

Authors:  M M Rechler; L Fryklund; S Nissley; K Hall; J M Podskalny; A Skottner; A C Moses
Journal:  Eur J Biochem       Date:  1978-01-02

8.  Somatomedin-C receptor ontogeny and levels in porcine fetal and human cord serum.

Authors:  A J D'ercole; D B Foushee; L E Underwood
Journal:  J Clin Endocrinol Metab       Date:  1976-11       Impact factor: 5.958

9.  Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

Authors:  E Rinderknecht; R E Humbel
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

10.  The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

Authors:  E Rinderknecht; R E Humbel
Journal:  J Biol Chem       Date:  1978-04-25       Impact factor: 5.157
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  6 in total

1.  Growth requirements in vitro of oligodendrocyte cell lines and neonatal rat brain oligodendrocytes.

Authors:  J E Bottenstein
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

2.  Assessment of growth hormone insulin like growth factor-I axis in Down's syndrome.

Authors:  A Barreca; A Rasore Quartino; M S Acutis; P Ponzani; G Damonte; E Miani; V Balestra; G Giordano; F Minuto
Journal:  J Endocrinol Invest       Date:  1994-06       Impact factor: 4.256

3.  Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

Authors:  V R Sara; C Carlsson-Skwirut; C Andersson; E Hall; B Sjögren; A Holmgren; H Jörnvall
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

4.  Somatomedins in tumour cyst fluid, cerebrospinal fluid, and tumour cytosol in patients with glial tumours.

Authors:  P Prisell; L Persson; J Boethius; V Sara
Journal:  Acta Neurochir (Wien)       Date:  1987       Impact factor: 2.216

5.  Transferrin as a fetal growth factor: acquisition of responsiveness related to embryonic induction.

Authors:  P Ekblom; I Thesleff; L Saxén; A Miettinen; R Timpl
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

6.  Ontogenesis of somatomedin and insulin receptors in the human fetus.

Authors:  V R Sara; K Hall; M Misaki; L Fryklund; N Christensen; L Wetterberg
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808
  6 in total

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