Laura Evans1, Andrew Rhodes2, Waleed Alhazzani3, Massimo Antonelli4, Craig M Coopersmith5, Craig French6, Flávia R Machado7, Lauralyn Mcintyre8, Marlies Ostermann9, Hallie C Prescott10, Christa Schorr11, Steven Simpson12, W Joost Wiersinga13, Fayez Alshamsi14, Derek C Angus15, Yaseen Arabi16, Luciano Azevedo17, Richard Beale9, Gregory Beilman18, Emilie Belley-Cote19, Lisa Burry20, Maurizio Cecconi21,22, John Centofanti23, Angel Coz Yataco24, Jan De Waele25, R Phillip Dellinger11, Kent Doi26, Bin Du27, Elisa Estenssoro28, Ricard Ferrer29, Charles Gomersall30, Carol Hodgson31, Morten Hylander Møller32, Theodore Iwashyna33, Shevin Jacob34, Ruth Kleinpell35, Michael Klompas36,37, Younsuck Koh38, Anand Kumar39, Arthur Kwizera40, Suzana Lobo41, Henry Masur42, Steven McGloughlin43, Sangeeta Mehta44, Yatin Mehta45, Mervyn Mer46, Mark Nunnally47, Simon Oczkowski3, Tiffany Osborn48, Elizabeth Papathanassoglou49, Anders Perner50, Michael Puskarich51, Jason Roberts52,53,54,55, William Schweickert56, Maureen Seckel57, Jonathan Sevransky5, Charles L Sprung58,59, Tobias Welte60, Janice Zimmerman61, Mitchell Levy62. 1. Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA. leevans@uw.edu. 2. Adult Critical Care, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK. 3. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. 4. Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 5. Emory University School of Medicine, Atlanta, GA, USA. 6. Western Health, Melbourne, Australia. 7. Anesthesiology, Pain and Intensive Care Department, Federal University of São Paulo, Hospital of São Paulo, São Paulo, Brazil. 8. Ottawa Hospital, Ottawa, ON, Canada. 9. Guy's & St Thomas' Hospital, London, England, UK. 10. University of Michigan and VA Center for Clinical Management Research, Ann Arbor, MI, USA. 11. Cooper Health System, Camden, NJ, USA. 12. University of Kansas Medical Center, Kansas City, KS, USA. 13. ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis, Division of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. 14. Department of Internal Medicine, College of Medicine and Health Sciences, Emirates University, Al Ain, United Arab Emirates. 15. University of Pittsburgh Critical Care Medicine CRISMA Laboratory, Pittsburgh, PA, USA. 16. Intensive Care Department, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia. 17. School of Medicine, University of Sao Paulo, São Paulo, Brazil. 18. University of Minnesota, Minneapolis, MN, USA. 19. Population Health Research Institute, Hamilton, ON, Canada. 20. Mount Sinai Hospital & University of Toronto (Leslie Dan Faculty of Pharmacy), Toronto, ON, Canada. 21. Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy. 22. Department of Anaesthesia and Intensive Care, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. 23. Department of Anesthesia, McMaster University, Hamilton, ON, Canada. 24. Lexington Veterans Affairs Medical Center/University of Kentucky College of Medicine, Lexington, KY, USA. 25. Ghent University Hospital, Ghent, Belgium. 26. The University of Tokyo, Tokyo, Japan. 27. Medical ICU, Peking Union Medical College Hospital, Beijing, China. 28. Hospital Interzonal de Agudos San Martin de La Plata, Buenos Aires, Argentina. 29. Intensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Institut de Recerca, Barcelona, Spain. 30. Prince of Wales Hospital, Hong Kong, China. 31. Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia. 32. Department of Intensive Care 4131, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 33. University of Michigan Health System, Ann Arbor, MI, USA. 34. Liverpool School of Tropical Medicine, Liverpool, UK. 35. Vanderbilt University, Nashville, TN, USA. 36. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. 37. Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, MA, USA. 38. ASAN Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. 39. University of Manitoba, Winnipeg, MB, Canada. 40. Makerere University College of Health Sciences, Kampala, Uganda. 41. Intensive Care Division, Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil. 42. Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA. 43. Alfred Health, Melbourne, Australia. 44. Mount Sinai Hospital, Toronto, ON, Canada. 45. Medanta the Medicity, Gurugram, Haryana, India. 46. Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. 47. New York University School of Medicine, New York, NY, USA. 48. Washington University School of Medicine, St. Louis, MO, USA. 49. Faculty of Nursing, University of Alberta, Edmonton, AB, Canada. 50. Rigshospitalet, Copenhagen, Denmark. 51. University of Minnesota/Hennepin County Medical Center, Minneapolis, MN, USA. 52. Faculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia. 53. Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia. 54. Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. 55. Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France. 56. University of Pennsylvania, Philadelphia, PA, USA. 57. ChristianaCare, Newark, DE, USA. 58. Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. 59. Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Center, Jerusalem, Israel. 60. Medizinische Hochschule Hannover and German Center of Lung Research (DZL), Hannover, Germany. 61. World Federation of Intensive and Critical Care, Brussels, Belgium. 62. Warren Alpert School of Medicine at Brown University, Providence, Rhode Island & Rhode Island Hospital, Providence, RI, USA.
Abstract
Entities:
Keywords:
Adults; Evidence based medicine; Guidelines; Sepsis; Septic shock
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