OBJECTIVE: This study aimed to assess the diagnostic accuracy of magnetic resonance elastography (MRE) in detecting hepatic fibrosis and determining clinically relevant stiffness cutoff values per stage of fibrosis. METHODS: This retrospective study assessed 1488 hepatic MRE evaluations performed at a single institution for 5 years. Mean liver stiffness measurements were collected from 282 patients who had an MRE study within 1 year of histopathologic analysis. Areas under receiver operating characteristic curves were calculated for each stage of fibrosis with nonparametric ordinal measures of accuracy, and Youden Index was determined. RESULTS: Mean liver stiffness measurement values were as follows: F0, 2.5± 0.55 kPa; F1, 3.1± 0.80 kPa; F2, 3.4±0.95 kPa; F3, 4.7±1.44 kPa; and F4, 7.9± 2.64 kPa. Nonparametric ordinal measures of accuracy per fibrosis stage were as follows: F0: 0.934, P < 0.001; F0-F1: 0.917, P < 0.001; F0-F2: 0.944, P < 0.001; and F0-F3: 0.941, P < 0.001. Youden Index values for fibrosis stages F2, F3, and F4 were 3.9, 4.0, and 4.5 kPa, respectively. CONCLUSIONS: Magnetic resonance elastography is an accurate diagnostic tool in assessing liver fibrosis.
OBJECTIVE: This study aimed to assess the diagnostic accuracy of magnetic resonance elastography (MRE) in detecting hepatic fibrosis and determining clinically relevant stiffness cutoff values per stage of fibrosis. METHODS: This retrospective study assessed 1488 hepatic MRE evaluations performed at a single institution for 5 years. Mean liver stiffness measurements were collected from 282 patients who had an MRE study within 1 year of histopathologic analysis. Areas under receiver operating characteristic curves were calculated for each stage of fibrosis with nonparametric ordinal measures of accuracy, and Youden Index was determined. RESULTS: Mean liver stiffness measurement values were as follows: F0, 2.5± 0.55 kPa; F1, 3.1± 0.80 kPa; F2, 3.4±0.95 kPa; F3, 4.7±1.44 kPa; and F4, 7.9± 2.64 kPa. Nonparametric ordinal measures of accuracy per fibrosis stage were as follows: F0: 0.934, P < 0.001; F0-F1: 0.917, P < 0.001; F0-F2: 0.944, P < 0.001; and F0-F3: 0.941, P < 0.001. Youden Index values for fibrosis stages F2, F3, and F4 were 3.9, 4.0, and 4.5 kPa, respectively. CONCLUSIONS: Magnetic resonance elastography is an accurate diagnostic tool in assessing liver fibrosis.
Authors: Mathilde Wagner; Idoia Corcuera-Solano; Grace Lo; Steven Esses; Joseph Liao; Cecilia Besa; Nelson Chen; Ginu Abraham; Maggie Fung; James S Babb; Richard L Ehman; Bachir Taouli Journal: Radiology Date: 2017-01-03 Impact factor: 11.105
Authors: Sudhakar K Venkatesh; Michael L Wells; Frank H Miller; Kartik S Jhaveri; Alvin C Silva; Bachir Taouli; Richard L Ehman Journal: Abdom Radiol (NY) Date: 2018-07
Authors: Aparna Srinivasa Babu; Michael L Wells; Oleg M Teytelboym; Justin E Mackey; Frank H Miller; Benjamin M Yeh; Richard L Ehman; Sudhakar K Venkatesh Journal: Radiographics Date: 2016-09-30 Impact factor: 5.333
Authors: Siddharth Singh; Sudhakar K Venkatesh; Zhen Wang; Frank H Miller; Utaroh Motosugi; Russell N Low; Tarek Hassanein; Patrick Asbach; Edmund M Godfrey; Meng Yin; Jun Chen; Andrew P Keaveny; Mellena Bridges; Anneloes Bohte; Mohammad Hassan Murad; David J Lomas; Jayant A Talwalkar; Richard L Ehman Journal: Clin Gastroenterol Hepatol Date: 2014-11-20 Impact factor: 11.382