Literature DB >> 3456557

Regulatory DNA elements localized remotely upstream from the drug-metabolizing cytochrome P-450c gene.

A Fujisawa-Sehara, K Sogawa, C Nishi, Y Fujii-Kuriyama.   

Abstract

We have investigated regulatory DNA elements in the expression of the drug metabolizing P-450c gene of rats. After combining the 5' flanking and upstream untranslated regions of the isolated P-450c gene with structural gene for chloramphenicol acetyltransferase (CAT), the fusion genes were transfected into cultured cells (Hepa-1 and L cells) for the assay of transient expression of CAT activity. CAT activity was expressed inducibly in response to 3-methylcholanthrene only in Hepa-1 cells. At least three regions containing regulatory DNA elements were indentified; one, which is present in the sequence from -44b to -0.2kb immediately upstream of the TATA box, functions in the basal level of transcription, and the other two which were located in the sequence from -0.8kb to -1.0kb and from -1.0kb to -6.3kb, enhance in combination, transcription in response to inducers in a manner independent of their orientation.

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Year:  1986        PMID： 3456557      PMCID： PMC339517          DOI： 10.1093/nar/14.3.1465

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  24 in total

Review 1.  Multiplicity of mammalian microsomal cytochromes P-45.

Authors:  A Y Lu; S B West
Journal:  Pharmacol Rev       Date:  1979-12       Impact factor: 25.468

Review 2.  Isolation and purification of cytochrome P-450, and the existence of multiple forms.

Authors:  F P Guengerich
Journal:  Pharmacol Ther       Date:  1979       Impact factor: 12.310

3.  Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

Authors:  F J Gonzalez; S Kimura; D W Nebert
Journal:  J Biol Chem       Date:  1985-04-25       Impact factor: 5.157

4.  Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences.

Authors:  M Lusky; M Botchan
Journal:  Nature       Date:  1981-09-03       Impact factor: 49.962

5.  Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.

Authors:  L A Laimins; G Khoury; C Gorman; B Howard; P Gruss
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

Review 6.  Organization and expression of eucaryotic split genes coding for proteins.

Authors:  R Breathnach; P Chambon
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

7.  Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo.

Authors:  R Grosschedl; M L Birnstiel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

8.  Regulatory gene product of the Ah complex. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene binding to several moieties in mouse liver cytosol.

Authors:  R R Hannah; D W Nebert; H J Eisen
Journal:  J Biol Chem       Date:  1981-05-10       Impact factor: 5.157

9.  Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Authors:  A Poland; E Glover; A S Kende
Journal:  J Biol Chem       Date:  1976-08-25       Impact factor: 5.157

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  28 in total

1.  Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.

Authors:  Y V Sun; D R Boverhof; L D Burgoon; M R Fielden; T R Zacharewski
Journal:  Nucleic Acids Res       Date:  2004-08-24       Impact factor: 16.971

2.  Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression.

Authors:  C A Telakowski-Hopkins; R G King; C B Pickett
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

Review 3.  The Ah receptor and the mechanism of dioxin toxicity.

Authors:  J P Landers; N J Bunce
Journal:  Biochem J       Date:  1991-06-01       Impact factor: 3.857

4.  cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).

Authors:  K Hirose; M Morita; M Ema; J Mimura; H Hamada; H Fujii; Y Saijo; O Gotoh; K Sogawa; Y Fujii-Kuriyama
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

5.  Multiple DNA-binding factors interact with overlapping specificities at the aryl hydrocarbon response element of the cytochrome P450IA1 gene.

Authors:  F Saatcioglu; D J Perry; D S Pasco; J B Fagan
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

6.  Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

Authors:  J Hapgood; S Cuthill; M Denis; L Poellinger; J A Gustafsson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

7.  A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.

Authors:  A Yanagida; K Sogawa; K I Yasumoto; Y Fujii-Kuriyama
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

8.  Regulation of the chicken embryonic myosin light-chain (L23) gene: existence of a common regulatory element shared by myosin alkali light-chain genes.

Authors:  T Uetsuki; Y Nabeshima; A Fujisawa-Sehara; Y Nabeshima
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

9.  Transcriptional activation domains of the Ah receptor and Ah receptor nuclear translocator.

Authors:  K Sogawa; K Iwabuchi; H Abe; Y Fujii-Kuriyama
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

10.  Altered DNA binding specificity of Arnt by selection of partner bHLH-PAS proteins.

Authors:  Koshi Kinoshita; Yasuo Kikuchi; Yukie Sasakura; Masashi Suzuki; Yoshiaki Fujii-Kuriyama; Kazuhiro Sogawa
Journal:  Nucleic Acids Res       Date:  2004-06-09       Impact factor: 16.971
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