| Literature DB >> 20429575 |
Chunwei Cheng1, Lili Pan, Yi Chen, Hao Song, Yong Qin, Rongshi Li.
Abstract
The first total synthesis of marine natural product, (+/-)-marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.Entities:
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Year: 2010 PMID： 20429575 DOI： 10.1021/cc100052j
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766