Literature DB >> 34528212

A one-pot synthesis of piperidinium spirooxindoline-pyridineolates and indole-substituted pyridones in aqueous or ethanol medium.

Faezeh Mirzaei1, Mohammad Bayat2, Shima Nasri1.   

Abstract

Piperidinium spirooxindoline-pyridineolate has been prepared via one-pot multicomponent reaction of isatin, malononitrile, cyanoacetohydrazide, and piperidine in water or ethanol medium at room temperature. In addition, the synthesis of two indole-substituted 2-pyridones from indole-3-carbaldehyde, malononitrile, and cyanoacetohydrazide in the presence of piperidine is described.
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Entities:  

Keywords:  Aqueous medium; Cyanoacetohydrazide; Indole-substituted oxopyridine; Piperidinium salt; Spirooxindolo pyridine

Mesh：

Substances：

Year:  2021        PMID： 34528212     DOI： 10.1007/s11030-021-10313-4

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   3.364


  14 in total

Review 1.  Drug discovery using spirooxindole cores: Success and Challenges [corrected].

Authors:  Bin Yu; Zhiqiang Yu; Ping-Ping Qi; De-Quan Yu; Hong-Min Liu
Journal:  Eur J Med Chem       Date:  2015-03-12       Impact factor: 6.514

2.  Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.

Authors:  Yuling Li; Hui Chen; Chunling Shi; Daqing Shi; Shunjun Ji
Journal:  J Comb Chem       Date:  2010-03-08

Review 3.  Therapeutic Potential of Spirooxindoles as Antiviral Agents.

Authors:  Na Ye; Haiying Chen; Eric A Wold; Pei-Yong Shi; Jia Zhou
Journal:  ACS Infect Dis       Date:  2016-05-05       Impact factor: 5.084

4.  Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark.

Authors:  R Rojas-Duran; G González-Aspajo; C Ruiz-Martel; G Bourdy; V H Doroteo-Ortega; J Alban-Castillo; G Robert; P Auberger; E Deharo
Journal:  J Ethnopharmacol       Date:  2012-07-27       Impact factor: 4.360

Review 5.  Spirooxindoles: Promising scaffolds for anticancer agents.

Authors:  Bin Yu; De-Quan Yu; Hong-Min Liu
Journal:  Eur J Med Chem       Date:  2014-06-27       Impact factor: 6.514

Review 6.  Spirooxindoles as Potential Pharmacophores.

Authors:  Siva S Panda; Rachel A Jones; Praveen Bachawala; Prabhu P Mohapatra
Journal:  Mini Rev Med Chem       Date:  2017       Impact factor: 3.862

7.  Recent advances in spirocyclization of indole derivatives.

Authors:  Jitender Bariwal; Leonid G Voskressensky; Erik V Van der Eycken
Journal:  Chem Soc Rev       Date:  2018-06-05       Impact factor: 54.564

Review 8.  Strategies for the enantioselective synthesis of spirooxindoles.

Authors:  Nicolas R Ball-Jones; Joseph J Badillo; Annaliese K Franz
Journal:  Org Biomol Chem       Date:  2012-05-14       Impact factor: 3.876

9.  Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.

Authors:  Tai-Hyun Kang; Kinzo Matsumoto; Michihisa Tohda; Yukihisa Murakami; Hiromitsu Takayama; Mariko Kitajima; Norio Aimi; Hiroshi Watanabe
Journal:  Eur J Pharmacol       Date:  2002-05-24       Impact factor: 4.432

10.  K13 Propeller Mutations in Plasmodium falciparum Populations in Regions of Malaria Endemicity in Vietnam from 2009 to 2016.

Authors:  Nguyen Thuy-Nhien; Nguyen Kim Tuyen; Nguyen Thanh Tong; Nguyen Tuong Vy; Ngo Viet Thanh; Huynh Thuy Van; Pham Huong-Thu; Huynh Hong Quang; Maciej F Boni; Christiane Dolecek; Jeremy Farrar; Guy E Thwaites; Olivo Miotto; Nicholas J White; Tran Tinh Hien
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191
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