Siva S Panda 1 , Rachel A Jones 2 , Praveen Bachawala 3 , Prabhu P Mohapatra 1 Show Affiliations »
Abstract
OBJECTIVE: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. BACKGROUND: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. CONCLUSION: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
OBJECTIVE: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. BACKGROUND: Over the past few decades, various spirooxindole -containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. CONCLUSION: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Keywords:
Biological importance; chemistry; heterocycles; pharmacophores; spirooxindoles; synthesis
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Year: 2017
PMID： 29056096 DOI： 10.2174/1389557516666160624125108
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862