Literature DB >> 20085353

Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.

Yuling Li1, Hui Chen, Chunling Shi, Daqing Shi, Shunjun Ji.   

Abstract

An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.

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Year:  2010        PMID： 20085353     DOI： 10.1021/cc9001185

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  15 in total

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