S Christy Sadreameli1, Ammara Ahmed2, Jean Curtin-Brosnan3, Matthew S Perzanowski4, Wanda Phipatanakul5, Susan Balcer-Whaley3, Adnan Divjan4, Roger D Peng6, Michelle Newman3, Amparito Cunningham4, Mary E Bollinger7, Robert A Wise8, Rachel L Miller9, Elizabeth C Matsui10. 1. Eudowood Division of Pediatric Respiratory Sciences, School of Medicine, Johns Hopkins University, Baltimore, Md. Electronic address: ssadrea1@jhmi.edu. 2. Division of Pediatric Allergy and Immunology, Children's National Medical Center, Washington, DC. 3. Division of Pediatric Allergy/Immunology, Johns Hopkins University School of Medicine, Baltimore, Md. 4. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY. 5. Division of Pediatric Allergy/Immunology, Boston Children's Hospital, Harvard University Medical School, Boston, Mass. 6. Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md. 7. Division of Pediatric Pulmonology/Allergy, University of Maryland School of Medicine, Baltimore, Md. 8. Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Md. 9. Division of Clinical Immunology, Departments of Medicine and Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY. 10. Departments of Population Health and Pediatrics, Dell Medical School at University of Texas at Austin, Austin, Texas.
Abstract
BACKGROUND: Whether concomitant home exposures modify the effectiveness of mouse allergen reduction among mouse-sensitized children with asthma is unknown. OBJECTIVE: To determine whether a lower baseline home mouse allergen level, lower particulate matter 10 μ or less (PM10), and the absence of sensitization and exposure to other indoor allergens are associated with greater improvements in asthma associated with mouse allergen reduction. METHODS: A secondary analysis of a randomized clinical trial of a home mouse allergen intervention was performed to examine the effect of 3 indoor factors on the relationship between mouse allergen reduction and a range of asthma outcomes. RESULTS: Participants (N = 297) were predominantly minority (78% African American, 22% Hispanic) and publicly insured (88%). Higher baseline mouse allergen levels were associated with a greater response to mouse allergen reduction for several symptom and exacerbation outcomes. Lower indoor PM10 levels were associated with a greater response to mouse allergen reduction for several symptom outcomes, but not exacerbation outcomes. Overall, sensitization and exposure to other indoor allergens did not appear to modify the effect of mouse allergen reduction. CONCLUSIONS: In this population of predominantly low-income children with persistent asthma and mouse sensitization, mouse allergen reduction was associated with improvements in asthma, especially among those with high baseline mouse allergen exposure. Lower indoor PM10 was associated with greater improvements in asthma symptoms.
BACKGROUND: Whether concomitant home exposures modify the effectiveness of mouse allergen reduction among mouse-sensitized children with asthma is unknown. OBJECTIVE: To determine whether a lower baseline home mouse allergen level, lower particulate matter 10 μ or less (PM10), and the absence of sensitization and exposure to other indoor allergens are associated with greater improvements in asthma associated with mouse allergen reduction. METHODS: A secondary analysis of a randomized clinical trial of a home mouse allergen intervention was performed to examine the effect of 3 indoor factors on the relationship between mouse allergen reduction and a range of asthma outcomes. RESULTS: Participants (N = 297) were predominantly minority (78% African American, 22% Hispanic) and publicly insured (88%). Higher baseline mouse allergen levels were associated with a greater response to mouse allergen reduction for several symptom and exacerbation outcomes. Lower indoor PM10 levels were associated with a greater response to mouse allergen reduction for several symptom outcomes, but not exacerbation outcomes. Overall, sensitization and exposure to other indoor allergens did not appear to modify the effect of mouse allergen reduction. CONCLUSIONS: In this population of predominantly low-income children with persistent asthma and mouse sensitization, mouse allergen reduction was associated with improvements in asthma, especially among those with high baseline mouse allergen exposure. Lower indoor PM10 was associated with greater improvements in asthma symptoms.
Authors: S Batterman; L Du; G Mentz; B Mukherjee; E Parker; C Godwin; J-Y Chin; A O'Toole; T Robins; Z Rowe; T Lewis Journal: Indoor Air Date: 2012-02-04 Impact factor: 5.770
Authors: Torie Grant; Charles Aloe; Matthew Perzanowski; Wanda Phipatanakul; Mary E Bollinger; Rachel Miller; Elizabeth C Matsui Journal: J Allergy Clin Immunol Pract Date: 2016-12-05
Authors: Rebecca S Gruchalla; Jacqueline Pongracic; Marshall Plaut; Richard Evans; Cynthia M Visness; Michelle Walter; Ellen F Crain; Meyer Kattan; Wayne J Morgan; Suzanne Steinbach; James Stout; George Malindzak; Ernestine Smartt; Herman Mitchell Journal: J Allergy Clin Immunol Date: 2005-03 Impact factor: 10.793
Authors: Sharon K Ahluwalia; Roger D Peng; Patrick N Breysse; Gregory B Diette; Jean Curtin-Brosnan; Charles Aloe; Elizabeth C Matsui Journal: J Allergy Clin Immunol Date: 2013-06-26 Impact factor: 10.793
Authors: Ammara Ahmed; S Christy Sadreameli; Jean Curtin-Brosnan; Torie Grant; Wanda Phipatanakul; Matthew Perzanowski; Susan Balcer-Whaley; Roger Peng; Michelle Newman; Amparito Cunningham; Adnan Divjan; Mary E Bollinger; Robert A Wise; Rachel Miller; Ginger Chew; Elizabeth C Matsui Journal: J Allergy Clin Immunol Pract Date: 2019-09-11