Literature DB >> 34496226

Glucocorticoid resistance and hyperlactatemia: A tag team to worsen sepsis.

Monowar Aziz1, Ping Wang1.   

Abstract

Glucocorticoid resistance often dims glucocorticoid's therapeutic efficacy in sepsis. However, the mechanism is incompletely understood. In this issue, Vandewalle et al. (2021) demonstrate that glucocorticoid resistance leads to hyperlactatemia and that this combination facilitates lethal sepsis. This insight gives important clarity to the pathophysiology of sepsis, while further suggesting therapeutic avenues for its treatment.
Copyright © 2021 Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34496226      PMCID： PMC9059133          DOI： 10.1016/j.cmet.2021.08.007

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   31.373


  10 in total

1.  Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis.

Authors:  Fang Fang; Yu Zhang; Jingjing Tang; L Dade Lunsford; Tiangui Li; Rongrui Tang; Jialing He; Ping Xu; Andrew Faramand; Jianguo Xu; Chao You
Journal:  JAMA Intern Med       Date:  2019-02-01       Impact factor: 21.873

Review 2.  Immune regulation by glucocorticoids.

Authors:  Derek W Cain; John A Cidlowski
Journal:  Nat Rev Immunol       Date:  2017-02-13       Impact factor: 53.106

3.  Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.

Authors:  Djillali Annane; Alain Renault; Christian Brun-Buisson; Bruno Megarbane; Jean-Pierre Quenot; Shidasp Siami; Alain Cariou; Xavier Forceville; Carole Schwebel; Claude Martin; Jean-François Timsit; Benoît Misset; Mohamed Ali Benali; Gwenhael Colin; Bertrand Souweine; Karim Asehnoune; Emmanuelle Mercier; Loïc Chimot; Claire Charpentier; Bruno François; Thierry Boulain; Franck Petitpas; Jean-Michel Constantin; Gilles Dhonneur; François Baudin; Alain Combes; Julien Bohé; Jean-François Loriferne; Roland Amathieu; Fabrice Cook; Michel Slama; Olivier Leroy; Gilles Capellier; Auguste Dargent; Tarik Hissem; Virginie Maxime; Eric Bellissant
Journal:  N Engl J Med       Date:  2018-03-01       Impact factor: 91.245

4.  Early administration of hydrocortisone replacement after the advent of septic shock: impact on survival and immune response*.

Authors:  Chrysostomos S Katsenos; Anastasia N Antonopoulou; Efterpi N Apostolidou; Aikaterini Ioakeimidou; Georgia Th Kalpakou; Metaxia N Papanikolaou; Aikaterini C Pistiki; Margarita C Mpalla; Michael D Paraschos; Maria A Patrani; Maria E Pratikaki; Theodoros A Retsas; Athina A Savva; Spyridoula D Vassiliagkou; Alexandra A Lekkou; Ioanna Dimopoulou; Christina Routsi; Konstantinos E Mandragos
Journal:  Crit Care Med       Date:  2014-07       Impact factor: 7.598

Review 5.  Mechanisms and treatment of organ failure in sepsis.

Authors:  Christophe Lelubre; Jean-Louis Vincent
Journal:  Nat Rev Nephrol       Date:  2018-07       Impact factor: 28.314

6.  Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.

Authors:  Balasubramanian Venkatesh; Simon Finfer; Jeremy Cohen; Dorrilyn Rajbhandari; Yaseen Arabi; Rinaldo Bellomo; Laurent Billot; Maryam Correa; Parisa Glass; Meg Harward; Christopher Joyce; Qiang Li; Colin McArthur; Anders Perner; Andrew Rhodes; Kelly Thompson; Steve Webb; John Myburgh
Journal:  N Engl J Med       Date:  2018-01-19       Impact factor: 91.245

7.  Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.

Authors:  Kiichiro Yano; Patricia C Liaw; Janet M Mullington; Shu-Ching Shih; Hitomi Okada; Natalya Bodyak; Peter M Kang; Lisa Toltl; Bryan Belikoff; Jon Buras; Benjamin T Simms; Joseph P Mizgerd; Peter Carmeliet; S Ananth Karumanchi; William C Aird
Journal:  J Exp Med       Date:  2006-05-15       Impact factor: 14.307

Review 8.  A General Introduction to Glucocorticoid Biology.

Authors:  Steven Timmermans; Jolien Souffriau; Claude Libert
Journal:  Front Immunol       Date:  2019-07-04       Impact factor: 7.561

9.  Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis.

Authors:  Jolien Vandewalle; Steven Timmermans; Ville Paakinaho; Lies Vancraeynest; Liza Dewyse; Tineke Vanderhaeghen; Charlotte Wallaeys; Lise Van Wyngene; Kelly Van Looveren; Louise Nuyttens; Melanie Eggermont; Sylviane Dewaele; Tiago R Velho; Luis F Moita; Sebastian Weis; Christoph Sponholz; Leo A van Grunsven; Mieke Dewerchin; Peter Carmeliet; Karolien De Bosscher; Johan Van de Voorde; Jorma J Palvimo; Claude Libert
Journal:  Cell Metab       Date:  2021-07-23       Impact factor: 27.287

10.  The influence of gender on the epidemiology of and outcome from severe sepsis.

Authors:  Yasser Sakr; Cristina Elia; Luciana Mascia; Bruno Barberis; Silvano Cardellino; Sergio Livigni; Gilberto Fiore; Claudia Filippini; Vito Marco Ranieri
Journal:  Crit Care       Date:  2013-03-18       Impact factor: 9.097
  10 in total

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