Literature DB >> 34495810

Vaccines efficacy to SARS-CoV-2 variants require holistic knowledge of viral immunology and protein biochemistry.

Sachin Kumar1.   

Abstract

The article by Abdalla et al., published in the journal on 28 May 2021, raised a concern. The SARS-CoV-2 spike (S) protein is the major targeted surface glycoprotein in COVID-19 vaccines. Many mutations in the S protein of SARS-CoV-2 have been reported across the globe. The S protein plays a crucial role in the induction of neutralizing antibody and protective immunity against SARS-CoV-2 infection. The protein biochemistry and immunology, in addition to conventional virology, will help us to delineate the biology of SARS-CoV-2 variants.

Entities:  

Keywords:  Variants; biochemistry; immunity; receptor; spike

Mesh：

Substances：

Year:  2021        PMID： 34495810      PMCID： PMC8828121          DOI： 10.1080/21645515.2021.1964318

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   4.526


  17 in total

1.  Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages.

Authors:  Y Zhang; N Chirmule; G P Gao; R Qian; M Croyle; B Joshi; J Tazelaar; J M Wilson
Journal:  Mol Ther       Date:  2001-05       Impact factor: 11.454

2.  SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.

Authors:  Jinal N Bhiman; Penny L Moore; Constantinos Kurt Wibmer; Frances Ayres; Tandile Hermanus; Mashudu Madzivhandila; Prudence Kgagudi; Brent Oosthuysen; Bronwen E Lambson; Tulio de Oliveira; Marion Vermeulen; Karin van der Berg; Theresa Rossouw; Michael Boswell; Veronica Ueckermann; Susan Meiring; Anne von Gottberg; Cheryl Cohen; Lynn Morris
Journal:  Nat Med       Date:  2021-03-02       Impact factor: 53.440

3.  Spike mutation D614G alters SARS-CoV-2 fitness.

Authors:  Jessica A Plante; Yang Liu; Jianying Liu; Hongjie Xia; Bryan A Johnson; Kumari G Lokugamage; Xianwen Zhang; Antonio E Muruato; Jing Zou; Camila R Fontes-Garfias; Divya Mirchandani; Dionna Scharton; John P Bilello; Zhiqiang Ku; Zhiqiang An; Birte Kalveram; Alexander N Freiberg; Vineet D Menachery; Xuping Xie; Kenneth S Plante; Scott C Weaver; Pei-Yong Shi
Journal:  Nature       Date:  2020-10-26       Impact factor: 49.962

Review 4.  Antibody responses to viral infections: a structural perspective across three different enveloped viruses.

Authors:  Charles D Murin; Ian A Wilson; Andrew B Ward
Journal:  Nat Microbiol       Date:  2019-03-18       Impact factor: 17.745

5.  Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization.

Authors:  Pengfei Wang; Ryan G Casner; Manoj S Nair; Maple Wang; Jian Yu; Gabriele Cerutti; Lihong Liu; Peter D Kwong; Yaoxing Huang; Lawrence Shapiro; David D Ho
Journal:  Cell Host Microbe       Date:  2021-04-18       Impact factor: 21.023

6.  A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV.

Authors:  Meng Yuan; Nicholas C Wu; Xueyong Zhu; Chang-Chun D Lee; Ray T Y So; Huibin Lv; Chris K P Mok; Ian A Wilson
Journal:  Science       Date:  2020-04-03       Impact factor: 47.728

7.  SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.

Authors:  Lizhou Zhang; Cody B Jackson; Huihui Mou; Amrita Ojha; Haiyong Peng; Brian D Quinlan; Erumbi S Rangarajan; Andi Pan; Abigail Vanderheiden; Mehul S Suthar; Wenhui Li; Tina Izard; Christoph Rader; Michael Farzan; Hyeryun Choe
Journal:  Nat Commun       Date:  2020-11-26       Impact factor: 14.919

8.  Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.

Authors:  Bette Korber; Will M Fischer; Sandrasegaram Gnanakaran; Hyejin Yoon; James Theiler; Werner Abfalterer; Nick Hengartner; Elena E Giorgi; Tanmoy Bhattacharya; Brian Foley; Kathryn M Hastie; Matthew D Parker; David G Partridge; Cariad M Evans; Timothy M Freeman; Thushan I de Silva; Charlene McDanal; Lautaro G Perez; Haili Tang; Alex Moon-Walker; Sean P Whelan; Celia C LaBranche; Erica O Saphire; David C Montefiori
Journal:  Cell       Date:  2020-07-03       Impact factor: 66.850

9.  Are the new SARS-CoV-2 variants resistant against the vaccine?

Authors:  Mohnad Abdalla; Amr Ahmed El-Arabey; Xinyi Jiang
Journal:  Hum Vaccin Immunother       Date:  2021-05-28       Impact factor: 3.452

10.  Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant.

Authors:  Jamie Lopez Bernal; Nick Andrews; Charlotte Gower; Eileen Gallagher; Ruth Simmons; Simon Thelwall; Julia Stowe; Elise Tessier; Natalie Groves; Gavin Dabrera; Richard Myers; Colin N J Campbell; Gayatri Amirthalingam; Matt Edmunds; Maria Zambon; Kevin E Brown; Susan Hopkins; Meera Chand; Mary Ramsay
Journal:  N Engl J Med       Date:  2021-07-21       Impact factor: 91.245
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.