Literature DB >> 33654292

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.

Jinal N Bhiman1,2, Penny L Moore3,4, Constantinos Kurt Wibmer1, Frances Ayres1, Tandile Hermanus1, Mashudu Madzivhandila1, Prudence Kgagudi1, Brent Oosthuysen1, Bronwen E Lambson1,5, Tulio de Oliveira6, Marion Vermeulen7, Karin van der Berg7,8, Theresa Rossouw9, Michael Boswell10, Veronica Ueckermann10, Susan Meiring1, Anne von Gottberg1,11, Cheryl Cohen1,12, Lynn Morris1,5.   

Abstract

SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.

Entities:  

Year:  2021        PMID： 33654292     DOI： 10.1038/s41591-021-01285-x

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  2 in total

1.  Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2.

Authors:  Sham Nambulli; Zhengyun Xiao; Heng Liu; Yufei Xiang; Zhe Sang; W Paul Duprex; Dina Schneidman-Duhovny; Cheng Zhang; Yi Shi
Journal:  Science       Date:  2020-11-05       Impact factor: 47.728

2.  An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.

Authors:  Michael Schoof; Bryan Faust; Reuben A Saunders; Smriti Sangwan; Veronica Rezelj; Nick Hoppe; Morgane Boone; Christian B Billesbølle; Cristina Puchades; Caleigh M Azumaya; Huong T Kratochvil; Marcell Zimanyi; Ishan Deshpande; Jiahao Liang; Sasha Dickinson; Henry C Nguyen; Cynthia M Chio; Gregory E Merz; Michael C Thompson; Devan Diwanji; Kaitlin Schaefer; Aditya A Anand; Niv Dobzinski; Beth Shoshana Zha; Camille R Simoneau; Kristoffer Leon; Kris M White; Un Seng Chio; Meghna Gupta; Mingliang Jin; Fei Li; Yanxin Liu; Kaihua Zhang; David Bulkley; Ming Sun; Amber M Smith; Alexandrea N Rizo; Frank Moss; Axel F Brilot; Sergei Pourmal; Raphael Trenker; Thomas Pospiech; Sayan Gupta; Benjamin Barsi-Rhyne; Vladislav Belyy; Andrew W Barile-Hill; Silke Nock; Yuwei Liu; Nevan J Krogan; Corie Y Ralston; Danielle L Swaney; Adolfo García-Sastre; Melanie Ott; Marco Vignuzzi; Peter Walter; Aashish Manglik
Journal:  Science       Date:  2020-11-05       Impact factor: 63.714
  2 in total
  472 in total

Review 1.  Practical guidance for clinical laboratories for SARS-CoV-2 serology testing.

Authors:  Carmen Charlton; Jamil Kanji; Vanessa Tran; Julianne Kus; Jonathan Gubbay; Carla Osiowy; Jason Robinson; Inna Sekirov; Michael Drebot; Todd Hatchette; Derek Stein; Nadia El-Gabalawy; Amanda Lang; Lei Jiao; Paul Levett; Heidi Wood; Christian Therrien; L Robbin Lindsay; Muhammad Morshed; Jessica Forbes; Antonia Dibernardo
Journal:  Can Commun Dis Rep       Date:  2021-05-07

2.  SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies.

Authors:  Emanuele Andreano; Rino Rappuoli
Journal:  Nat Med       Date:  2021-05-10       Impact factor: 53.440

3.  Position paper on the use of COVID-19 convalescent plasma: an update.

Authors:  Daniele Prati; Francesco Fiorin; Pierluigi Berti; Giustina De Silvestro; Patrizia Accorsi; Angelo Ostuni
Journal:  Blood Transfus       Date:  2021-05-21       Impact factor: 3.443

4.  Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants.

Authors:  Zhiqiang Ku; Xuping Xie; Paul R Hinton; Xinli Liu; Xiaohua Ye; Antonio E Muruato; Dean C Ng; Sujit Biswas; Jing Zou; Yang Liu; Deepal Pandya; Vineet D Menachery; Sachi Rahman; Yu-An Cao; Hui Deng; Wei Xiong; Kevin B Carlin; Junquan Liu; Hang Su; Elizabeth J Haanes; Bruce A Keyt; Ningyan Zhang; Stephen F Carroll; Pei-Yong Shi; Zhiqiang An
Journal:  Nature       Date:  2021-06-03       Impact factor: 49.962

5.  Human Vaccines & Immunotherapeutics: news.

Authors: 
Journal:  Hum Vaccin Immunother       Date:  2021-03-04       Impact factor: 3.452

6.  Emergence and Spread of SARS-CoV-2 Lineages B.1.1.7 and P.1 in Italy.

Authors:  Francesca Di Giallonardo; Ilaria Puglia; Valentina Curini; Cesare Cammà; Iolanda Mangone; Paolo Calistri; Joanna C A Cobbin; Edward C Holmes; Alessio Lorusso
Journal:  Viruses       Date:  2021-04-29       Impact factor: 5.048

7.  Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.

Authors:  Yunlong Cao; Ayijiang Yisimayi; Yali Bai; Weijin Huang; Xiaofeng Li; Zhiying Zhang; Tianjiao Yuan; Ran An; Jing Wang; Tianhe Xiao; Shuo Du; Wenping Ma; Liyang Song; Yongzheng Li; Xiang Li; Weiliang Song; Jiajing Wu; Shuo Liu; Xuemei Li; Yonghong Zhang; Bin Su; Xianghua Guo; Yangyang Wei; Chuanping Gao; Nana Zhang; Yifei Zhang; Yang Dou; Xiaoyu Xu; Rui Shi; Bai Lu; Ronghua Jin; Yingmin Ma; Chengfeng Qin; Youchun Wang; Yingmei Feng; Junyu Xiao; Xiaoliang Sunney Xie
Journal:  Cell Res       Date:  2021-05-21       Impact factor: 25.617

8.  Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil.

Authors:  Carolina M Voloch; Ronaldo da Silva Francisco; Luiz G P de Almeida; Cynthia C Cardoso; Otavio J Brustolini; Alexandra L Gerber; Ana Paula de C Guimarães; Diana Mariani; Raissa Mirella da Costa; Orlando C Ferreira; Thiago Silva Frauches; Claudia Maria Braga de Mello; Isabela de Carvalho Leitão; Rafael Mello Galliez; Débora Souza Faffe; Terezinha M P P Castiñeiras; Amilcar Tanuri; Ana Tereza R de Vasconcelos
Journal:  J Virol       Date:  2021-03-01       Impact factor: 5.103

9.  Epidemiology and genetic diversity of SARS-CoV-2 lineages circulating in Africa.

Authors:  Olayinka Sunday Okoh; Nicholas Israel Nii-Trebi; Abdulrokeeb Jakkari; Tosin Titus Olaniran; Tosin Yetunde Senbadejo; Anna Aba Kafintu-Kwashie; Emmanuel Oluwatobi Dairo; Tajudeen Oladunni Ganiyu; Ifiokakaninyene Ekpo Akaninyene; Louis Odinakaose Ezediuno; Idowu Jesulayomi Adeosun; Michael Asebake Ockiya; Esther Moradeyo Jimah; David J Spiro; Elijah Kolawole Oladipo; Nídia S Trovão
Journal:  medRxiv       Date:  2021-05-19

10.  E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

Authors:  Patrícia Aline Gröhs Ferrareze; Vinícius Bonetti Franceschi; Amanda de Menezes Mayer; Gabriel Dickin Caldana; Ricardo Ariel Zimerman; Claudia Elizabeth Thompson
Journal:  Infect Genet Evol       Date:  2021-05-25       Impact factor: 4.393
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