Adrian A Schmid1, John N Morelli2, Martin N Hungerbühler3, Ingrid B Boehm3. 1. Department of Orthopaedics and Traumatology, Spital Altstaetten, Altstaetten, Switzerland. 2. Department of Radiology, St. John's Medical Center Tulsa, OK, USA. 3. Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University of Bern, Bern, Switzerland.
Abstract
BACKGROUND: Although several papers deal with "cross-reactivity" in patients with iodinated contrast medium (ICM) hypersensitivity reactions (HSRs), there is no in-depth knowledge of this phenomenon. To define ICM-groups as potential reaction partners and to identify any potential clinical relevance in patients with ICM-HSRs. METHODS: The literature database PubMed was searched for eligible papers dealing with ICM-allergy and "cross-reactivity". The data presented by the papers was analyzed and individual patient data was extracted for re-evaluation based on a definition for both 'polyvalent reactivity' and 'cross-reactivity' as well as for chemical structure-dependent ICM-groups. RESULTS: Twenty-five original papers (with n=340 extracted patients) formed the study population. Incidences of polyvalent reactivity were non-significantly higher than incidences of cross-reactivity (both range from 0% to 100%). Crossover evaluation in reaction pairings (culprit ICM A with ICM B versus culprit ICM B with ICM A) showed concordance of only 30%. Data support rather non-cross-reactivity (individual reaction pattern) than cross-reactivity constellations. CONCLUSIONS: The obtained results favour an individual reaction pattern, rather than a reactivity driven by chemical structures and so-called cross-reactivity. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: Although several papers deal with "cross-reactivity" in patients with iodinated contrast medium (ICM) hypersensitivity reactions (HSRs), there is no in-depth knowledge of this phenomenon. To define ICM-groups as potential reaction partners and to identify any potential clinical relevance in patients with ICM-HSRs. METHODS: The literature database PubMed was searched for eligible papers dealing with ICM-allergy and "cross-reactivity". The data presented by the papers was analyzed and individual patient data was extracted for re-evaluation based on a definition for both 'polyvalent reactivity' and 'cross-reactivity' as well as for chemical structure-dependent ICM-groups. RESULTS: Twenty-five original papers (with n=340 extracted patients) formed the study population. Incidences of polyvalent reactivity were non-significantly higher than incidences of cross-reactivity (both range from 0% to 100%). Crossover evaluation in reaction pairings (culprit ICM A with ICM B versus culprit ICM B with ICM A) showed concordance of only 30%. Data support rather non-cross-reactivity (individual reaction pattern) than cross-reactivity constellations. CONCLUSIONS: The obtained results favour an individual reaction pattern, rather than a reactivity driven by chemical structures and so-called cross-reactivity. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Entities:
Keywords:
Cross-reactivity; drug provocation test (DPT); hypersensitivity reaction (HSR); immediate reaction (IR); iodinated contrast medium (ICM); non-immediate reaction (NIR); polyvalent reactions; risk stratification
Authors: K Brockow; A Romano; W Aberer; A J Bircher; A Barbaud; P Bonadonna; E Faria; G Kanny; M Lerch; W J Pichler; J Ring; J Rodrigues Cernadas; E Tomaz; P Demoly; C Christiansen Journal: Allergy Date: 2009-02 Impact factor: 13.146
Authors: M J Torres; F Gomez; I Doña; A Rosado; C Mayorga; I Garcia; N Blanca-Lopez; G Canto; M Blanca Journal: Allergy Date: 2012-05-15 Impact factor: 13.146