Literature DB >> 3443150

Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.

J M Streete1, D J Berry, J E Newberry, P Crome.   

Abstract

The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a study previously performed in young volunteers.

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Year:  1987        PMID： 3443150     DOI： 10.1007/BF00637644

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  11 in total

1.  Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males.

Authors:  D F DAVIES; N W SHOCK
Journal:  J Clin Invest       Date:  1950-05       Impact factor: 14.808

Review 2.  Use of serum creatinine concentrations to determine renal function.

Authors:  T D Bjornsson
Journal:  Clin Pharmacokinet       Date:  1979 May-Jun       Impact factor: 6.447

3.  Gas chromatographic analysis of phenylethylmalonamide in human plasma.

Authors:  J M Streete; D J Berry
Journal:  J Chromatogr       Date:  1987-05-15

4.  Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration.

Authors:  B B Gallagher; I P Baumel; R H Mattson
Journal:  Neurology       Date:  1972-11       Impact factor: 9.910

5.  Primidone metabolism in renal insufficiency and acute intoxication.

Authors:  R Heipertz; A Guthoff; W Bernhardt
Journal:  J Neurol       Date:  1979-08       Impact factor: 4.849

6.  Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration.

Authors:  F Pisani; A Richens
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

7.  Pharmacokinetics of phenylethylmalonamide (PEMA) in normal subjects and in patients treated with antiepileptic drugs.

Authors:  P R Cottrell; J M Streete; D J Berry; H Schäfer; F Pisani; E Perucca; A Richens
Journal:  Epilepsia       Date:  1982-06       Impact factor: 5.864

8.  Phenylethylmalonamide (PEMA). An important metabolite of primidone.

Authors:  I P Baumel; B B Gallagher; R H Mattson
Journal:  Arch Neurol       Date:  1972-07

9.  Possible phenylethylmalondiamide (PEMA) intoxication.

Authors:  E L Stern
Journal:  Ann Neurol       Date:  1977-10       Impact factor: 10.422

10.  Phenylethylmalonamide in essential tremor. A double-blind controlled study.

Authors:  S Calzetti; L J Findley; F Pisani; A Richens
Journal:  J Neurol Neurosurg Psychiatry       Date:  1981-10       Impact factor: 10.154
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