Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Phenylethylmalonamide in essential tremor. A double-blind controlled study.

Literature DB >> 7031184

Phenylethylmalonamide in essential tremor. A double-blind controlled study.

S Calzetti, L J Findley, F Pisani, A Richens.

Abstract

A randomised double-blind placebo-controlled trial of phenylethylmalonamide, the major metabolite of primidone was performed in eight patients with essential tremor. Phenylethylmalonamide was given in a daily dose of 400 mg for one week and 800 mg for a second week. The compound had no statistically significant effect on the amplitude of tremor assessed by an accelerometric method, tests of performance, clinical evaluation and patient self assessment. No side effects occurred. Serum levels of phenylethylmalonamide on a daily dose of 400 mg were 11-27 micrograms/ml and on 800 mg daily were 16-48.5 micrograms/ml.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1981 PMID： 7031184 PMCID： PMC491180 DOI： 10.1136/jnnp.44.10.932

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

2 in total

1. Essential tremor treated with propranolol: lack of correlation between clinical effect and plasma propranolol levels.

Authors: P S Sørensen; O B Paulson; E Steiness; E C Jansen
Journal: Ann Neurol Date: 1981-01 Impact factor: 10.422

2. Benign familial tremor treated with primidone.

Authors: M D O'Brien; A R Upton; P A Toseland
Journal: Br Med J (Clin Res Ed) Date: 1981-01-17

2 in total

15 in total

Review 1. The clinical use of barbiturates in neurological disorders.

Authors: M C Smith; B J Riskin
Journal: Drugs Date: 1991-09 Impact factor: 9.546

2. Double-blind controlled study of primidone in essential tremor: preliminary results.

Authors: L J Findley; S Calzetti
Journal: Br Med J (Clin Res Ed) Date: 1982 Aug 28-Sep 4

3. Double-blind controlled study of primidone in essential tremor.

Authors: W R Gibb
Journal: Br Med J (Clin Res Ed) Date: 1982-10-16

4. Update on treatment of essential tremor.

Authors: Theresa A Zesiewicz; Jessica D Shaw; Kevin G Allison; Joseph S Staffetti; Michael S Okun; Kelly L Sullivan
Journal: Curr Treat Options Neurol Date: 2013-08 Impact factor: 3.598

Review 5. Management of essential tremor.

Authors: Theresa A Zesiewicz; Elmyra Encarnacion; Robert A Hauser
Journal: Curr Neurol Neurosci Rep Date: 2002-07 Impact factor: 5.081

Review 6. Benefits and risks of pharmacological treatments for essential tremor.

Authors: Kelly E Lyons; Rajesh Pahwa; Cynthia L Comella; Mahmood S Eisa; Rodger J Elble; Stanley Fahn; Joseph Jankovic; Jorge L Juncos; William C Koller; William G Ondo; Kapil D Sethi; Matthew B Stern; Caroline M Tanner; Ron Tintner; Ray L Watts
Journal: Drug Saf Date: 2003 Impact factor: 5.606

Phenylethylmalonamide in essential tremor. A double-blind controlled study.

1. Essential tremor treated with propranolol: lack of correlation between clinical effect and plasma propranolol levels.

2. Benign familial tremor treated with primidone.

Review 1. The clinical use of barbiturates in neurological disorders.

2. Double-blind controlled study of primidone in essential tremor: preliminary results.

3. Double-blind controlled study of primidone in essential tremor.

4. Update on treatment of essential tremor.

Review 5. Management of essential tremor.

Review 6. Benefits and risks of pharmacological treatments for essential tremor.

7. The disposition of primidone in elderly patients.

8. Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration.

9. Primidone in essential tremor of the hands and head: a double blind controlled clinical study.

10. Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.