Literature DB >> 617272

Possible phenylethylmalondiamide (PEMA) intoxication.

E L Stern.   

Abstract

We have encountered a case of apparent intoxication with primidone (Mysoline) in a patient with severe renal impairment. Of interest were high serum levels of phenylethyl-malondiamide (PEMA), a metabolite of primidone.

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Year:  1977        PMID： 617272     DOI： 10.1002/ana.410020418

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  4 in total

1.  Primidone metabolism in renal insufficiency and acute intoxication.

Authors:  R Heipertz; A Guthoff; W Bernhardt
Journal:  J Neurol       Date:  1979-08       Impact factor: 4.849

2.  The disposition of primidone in elderly patients.

Authors:  C Martines; G Gatti; E Sasso; S Calzetti; E Perucca
Journal:  Br J Clin Pharmacol       Date:  1990-10       Impact factor: 4.335

3.  Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration.

Authors:  F Pisani; A Richens
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

4.  Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.

Authors:  J M Streete; D J Berry; J E Newberry; P Crome
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953
  4 in total

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