| Literature DB >> 34405319 |
Antonio Gil1, Pedro Quintero2, Andrea Mares1, Juan Ribera de Serra3, Manuel Ignacio Sánchez-Nevárez4, Manuel Miralles4.
Abstract
During the last years, several kinds of Embolic Protection Devices (EPD) have been developed, with the aim of minimizing complication caused by thrombi generated during Carotid Artery Stenting (CAS). These devices are capable of capturing small particles generated during the intervention, avoiding cerebral stroke and improving the outcomes of the surgery. However, they have associated complications, like the increase on flow resistance associated by their use or the lack of knowledge on their actual filtration efficiency for thrombi of low size. Current work proposes a validated computational methodology in order to predict the hemodynamic features and filtering efficiency of a commercial EPD. It will be observed how Computational Fluid Dynamics predicts pressure drop with fair agreement with the experimental measurements. Finally, this work analyzes the filtration efficiency and the influence of the distribution of injected particles on this parameter. The capabilities of the filter for retaining particles of diameter below the pore size is, additionally, discussed.Entities:
Keywords: Computational fluid dynamics; Discrete element method; Embolic protection device; Filtration efficiency; Hemodynamics
Mesh:
Year: 2021 PMID: 34405319 DOI: 10.1007/s10439-021-02846-4
Source DB: PubMed Journal: Ann Biomed Eng ISSN: 0090-6964 Impact factor: 3.934