Literature DB >> 34398404

Strategies for Browning Agent Delivery.

Wentao Zhang1, Tao Sheng1, Zhen Gu2,3,4,5, Yuqi Zhang6.   

Abstract

Obesity expands as a global climbing epidemic that is often correlated to cardiovascular diseases and endocrine disorders. Converting white adipocytes to brown adipocytes for enhanced energy expenditure has recently emerged as a promising anti-obesity treatment. However, the conventional approaches to apply browning agents systematically suffer from off-target effects, multiple dosage requirements, and poor patient compliance. To date, various delivery strategies have been reported to deliver browning agents for obesity treatment in a safer and more controllable manner. This review will discuss the latest designs in browning agent delivery systems with a focus on nanomedicines and transdermal patches.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  adipocyte; browning agent; drug delivery; nanoparticle; transdermal patch

Mesh：

Substances：

Year:  2021        PMID： 34398404     DOI： 10.1007/s11095-021-03081-1

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  47 in total

Review 1.  Obesity as a medical problem.

Authors:  P G Kopelman
Journal:  Nature       Date:  2000-04-06       Impact factor: 49.962

Review 2.  Medical consequences of obesity.

Authors:  George A Bray
Journal:  J Clin Endocrinol Metab       Date:  2004-06       Impact factor: 5.958

Review 3.  Mechanisms, Pathophysiology, and Management of Obesity.

Authors:  Steven B Heymsfield; Thomas A Wadden
Journal:  N Engl J Med       Date:  2017-01-19       Impact factor: 91.245

4.  Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.

Authors:  Thorsten Gnad; Saskia Scheibler; Ivar von Kügelgen; Camilla Scheele; Ana Kilić; Anja Glöde; Linda S Hoffmann; Laia Reverte-Salisa; Philipp Horn; Samet Mutlu; Ali El-Tayeb; Mathias Kranz; Winnie Deuther-Conrad; Peter Brust; Martin E Lidell; Matthias J Betz; Sven Enerbäck; Jürgen Schrader; Gennady G Yegutkin; Christa E Müller; Alexander Pfeifer
Journal:  Nature       Date:  2014-10-15       Impact factor: 49.962

Review 5.  The Common and Distinct Features of Brown and Beige Adipocytes.

Authors:  Kenji Ikeda; Pema Maretich; Shingo Kajimura
Journal:  Trends Endocrinol Metab       Date:  2018-01-20       Impact factor: 12.015

6.  Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016.

Authors:  Joana Araújo; Jianwen Cai; June Stevens
Journal:  Metab Syndr Relat Disord       Date:  2018-11-27       Impact factor: 1.894

Review 7.  The epidemiology of obesity.

Authors:  Cynthia L Ogden; Susan Z Yanovski; Margaret D Carroll; Katherine M Flegal
Journal:  Gastroenterology       Date:  2007-05       Impact factor: 22.682

Review 8.  Adipose tissue browning and metabolic health.

Authors:  Alexander Bartelt; Joerg Heeren
Journal:  Nat Rev Endocrinol       Date:  2013-10-22       Impact factor: 43.330

9.  Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

Authors:  Jun Wu; Pontus Boström; Lauren M Sparks; Li Ye; Jang Hyun Choi; An-Hoa Giang; Melin Khandekar; Kirsi A Virtanen; Pirjo Nuutila; Gert Schaart; Kexin Huang; Hua Tu; Wouter D van Marken Lichtenbelt; Joris Hoeks; Sven Enerbäck; Patrick Schrauwen; Bruce M Spiegelman
Journal:  Cell       Date:  2012-07-12       Impact factor: 41.582

10.  Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue.

Authors:  Yan Qiu; Yingmin Sun; Danqing Xu; Yuanyuan Yang; Xiaojian Liu; Yuda Wei; Yanhao Chen; Zhuanghui Feng; Shuang Li; Md Reyad-Ul Ferdous; Yongxu Zhao; Hongxi Xu; Yuanzhi Lao; Qiurong Ding
Journal:  EBioMedicine       Date:  2018-10-20       Impact factor: 8.143
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  2 in total

Review 1.  Transdermal Drug Delivery Systems and Their Use in Obesity Treatment.

Authors:  Zhiguo Li; Xuexun Fang; Dahai Yu
Journal:  Int J Mol Sci       Date:  2021-11-25       Impact factor: 5.923

Review 2.  Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities.

Authors:  Jing Li; Hongli Duan; Yan Liu; Lu Wang; Xing Zhou
Journal:  Pharmaceutics       Date:  2022-07-11       Impact factor: 6.525
  2 in total

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