| Literature DB >> 22796012 |
Jun Wu1, Pontus Boström, Lauren M Sparks, Li Ye, Jang Hyun Choi, An-Hoa Giang, Melin Khandekar, Kirsi A Virtanen, Pirjo Nuutila, Gert Schaart, Kexin Huang, Hua Tu, Wouter D van Marken Lichtenbelt, Joris Hoeks, Sven Enerbäck, Patrick Schrauwen, Bruce M Spiegelman.
Abstract
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:Entities:
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Year: 2012 PMID： 22796012 PMCID： PMC3402601 DOI： 10.1016/j.cell.2012.05.016
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582