Literature DB >> 34372899

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies.

Seyed Esmaeil Ahmadi1, Samira Rahimi1, Bahman Zarandi1, Rouzbeh Chegeni2, Majid Safa3,4.   

Abstract

MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.
© 2021. The Author(s).

Entities:  

Keywords:  Apoptosis; Cell cycle; DNA damage response; Hematological malignancies; MYC; Oncogene; Prognostic importance; Regulation; Therapeutic implications

Year:  2021        PMID： 34372899     DOI： 10.1186/s13045-021-01111-4

Source DB:  PubMed          Journal:  J Hematol Oncol        ISSN： 1756-8722            Impact factor:   17.388


  627 in total

1.  c-MYC protein is degraded in response to UV irradiation.

Authors:  Sébastien Britton; Bernard Salles; Patrick Calsou
Journal:  Cell Cycle       Date:  2007-10-02       Impact factor: 4.534

Review 2.  Reflecting on 25 years with MYC.

Authors:  Natalie Meyer; Linda Z Penn
Journal:  Nat Rev Cancer       Date:  2008-12       Impact factor: 60.716

Review 3.  Transcriptional regulation and transformation by Myc proteins.

Authors:  Sovana Adhikary; Martin Eilers
Journal:  Nat Rev Mol Cell Biol       Date:  2005-08       Impact factor: 94.444

4.  Potentiation of growth factor activity by exogenous c-myc expression.

Authors:  V Sorrentino; V Drozdoff; M D McKinney; L Zeitz; E Fleissner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

5.  Functional role for c-myc in mitogenic response to platelet-derived growth factor.

Authors:  H A Armelin; M C Armelin; K Kelly; T Stewart; P Leder; B H Cochran; C D Stiles
Journal:  Nature       Date:  1984 Aug 23-29       Impact factor: 49.962

6.  c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.

Authors:  Zuqin Nie; Gangqing Hu; Gang Wei; Kairong Cui; Arito Yamane; Wolfgang Resch; Ruoning Wang; Douglas R Green; Lino Tessarollo; Rafael Casellas; Keji Zhao; David Levens
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

Review 7.  Proteolytic control of the oncoprotein transcription factor Myc.

Authors:  Lance R Thomas; William P Tansey
Journal:  Adv Cancer Res       Date:  2011       Impact factor: 6.242

8.  c-Myc enhances protein synthesis and cell size during B lymphocyte development.

Authors:  B M Iritani; R N Eisenman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

Review 9.  c-MYC: more than just a matter of life and death.

Authors:  Stella Pelengaris; Mike Khan; Gerard Evan
Journal:  Nat Rev Cancer       Date:  2002-10       Impact factor: 60.716

10.  DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells.

Authors:  Tingting Ai; Jieni Zhang; Xuedong Wang; Xiaowen Zheng; Xueyan Qin; Qian Zhang; Weiran Li; Wei Hu; Jiuxiang Lin; Feng Chen
Journal:  Signal Transduct Target Ther       Date:  2018-01-12
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  9 in total

Review 1.  PROTACs: great opportunities for academia and industry (an update from 2020 to 2021).

Authors:  Ming He; Chaoguo Cao; Zhihao Ni; Yongbo Liu; Peilu Song; Shuang Hao; Yuna He; Xiuyun Sun; Yu Rao
Journal:  Signal Transduct Target Ther       Date:  2022-06-09

2.  A Novel BRD Family PROTAC Inhibitor dBET1 Exerts Great Anti-Cancer Effects by Targeting c-MYC in Acute Myeloid Leukemia Cells.

Authors:  Kunlong Zhang; Li Gao; Jianwei Wang; Xinran Chu; Zimu Zhang; Yongping Zhang; Fang Fang; Yanfang Tao; Xiaolu Li; Yuanyuan Tian; Zhiheng Li; Xu Sang; Li Ma; Lihui Lu; Yanling Chen; Juanjuan Yu; Ran Zhuo; Shuiyan Wu; Jian Pan; Shaoyan Hu
Journal:  Pathol Oncol Res       Date:  2022-06-27       Impact factor: 2.874

3.  Editorial: Mouse Models of B Cell Malignancies.

Authors:  Gema Perez-Chacon; Christelle Vincent-Fabert; Juan M Zapata
Journal:  Front Immunol       Date:  2021-10-28       Impact factor: 7.561

4.  Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression.

Authors:  Tianqi Wu; Wenfeng Wang; Guohai Shi; Mingang Hao; Yingying Wang; Mengfei Yao; Yongqiang Huang; Leilei Du; Xingming Zhang; Dingwei Ye; Xiaojie Bian; Jianhua Wang
Journal:  Cell Death Dis       Date:  2022-07-19       Impact factor: 9.685

5.  Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes.

Authors:  Guanyi Liu; Dingyang Li; Liwei Zhang; Qiuping Xu; Dexuan Zhuang; Panpan Liu; Ling Hu; Huiting Deng; Jianfeng Sun; Shuangshuang Wang; Bin Zheng; Jing Guo; Xunwei Wu
Journal:  Cells       Date:  2022-08-05       Impact factor: 7.666

Review 6.  Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring.

Authors:  Olga V Anatskaya; Alexander E Vinogradov
Journal:  Int J Mol Sci       Date:  2022-08-26       Impact factor: 6.208

7.  Andrographolide Induces G2/M Cell Cycle Arrest and Apoptosis in Human Glioblastoma DBTRG-05MG Cell Line via ERK1/2 /c-Myc/p53 Signaling Pathway.

Authors:  Nurul Syamimi Othman; Daruliza Kernain Mohd Azman
Journal:  Molecules       Date:  2022-10-08       Impact factor: 4.927

8.  The Rationale for the Dual-Targeting Therapy for RSK2 and AKT in Multiple Myeloma.

Authors:  Reiko Isa; Mano Horinaka; Taku Tsukamoto; Kentaro Mizuhara; Yuto Fujibayashi; Yoko Taminishi-Katsuragawa; Haruya Okamoto; Shusuke Yasuda; Yuka Kawaji-Kanayama; Yayoi Matsumura-Kimoto; Shinsuke Mizutani; Yuji Shimura; Masafumi Taniwaki; Toshiyuki Sakai; Junya Kuroda
Journal:  Int J Mol Sci       Date:  2022-03-08       Impact factor: 5.923

9.  8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells.

Authors:  Pei-Shan Wu; Chih-Yang Wang; Pin-Shern Chen; Jui-Hsiang Hung; Jui-Hung Yen; Ming-Jiuan Wu
Journal:  Biomedicines       Date:  2021-12-14
  9 in total

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