Literature DB >> 6088986

Functional role for c-myc in mitogenic response to platelet-derived growth factor.

H A Armelin, M C Armelin, K Kelly, T Stewart, P Leder, B H Cochran, C D Stiles.   

Abstract

In BALB/c-3T3 cells, expression of the c-myc gene is stimulated by platelet-derived growth factor (PDGF). Using mouse mammary tumour virus promoter: c-myc recombinant plasmids, 3T3 sublines were constructed in which hydrocortisone was the primary determinant of myc mRNA content. The c-myc gene product is an intracellular mediator of the growth response to PDGF though probably not the only one. Both the human and the mouse c-myc genes stimulate clonal growth of 3T3 cells in PDGF-free medium suggesting new strategies for analysis of oncogenes which do not function in focus formation assays.

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Year:  1984        PMID： 6088986     DOI： 10.1038/310655a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  155 in total

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