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Literature DB >> 343728

Sulindac. Trials of a new anti-inflammatory drug.

Abstract

Trials in patients with rheumatoid arthritis and osteoarthritis showed sulindac to be an analgesic with anti-inflammatory properties and at least as effective as aspirin. It was effective within 24 hours in doses of 300-400 mg daily. It had the advantages of twice daily administration and a lower incidence of gastric side effects than aspirin. Constipation, usually mild, occurred in 20-30% of cases. Like other anti-inflammatory drugs, it was effective in only a proportion of the patients.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1978 PMID： 343728 PMCID： PMC1000199 DOI： 10.1136/ard.37.1.89

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

5 in total

1. [Proceedings: Double-blind comparison of MK 231 with indomethacin in spondylitis ankylopoetica].

Authors: F W Gribnau; D A Lissone
Journal: Ned Tijdschr Geneeskd Date: 1975-07-12

2. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

Authors: D M Ritchie; J A Boyle; J M McInnes; M K Jasani; T G Dalakos; P Grieveson; W W Buchanan
Journal: Q J Med Date: 1968-07

3. Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis.

Authors: P L Boardman; F D Hart
Journal: Br Med J Date: 1967-11-04

4. Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.

Authors: H B Hucker; S C Stauffer; S D White; R E Rhodes; B H Arison; E R Umbenhauer; R J Bower; F G McMahon
Journal: Drug Metab Dispos Date: 1973 Nov-Dec Impact factor: 3.922

5. Sulindac in osteoarthrosis of the hip.

Authors: P A Dieppe; H C Burry; R Grahame; T Perera
Journal: Rheumatol Rehabil Date: 1976-05

5 in total

7 in total

Review 1. Sulindac: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.

Authors: R N Brogden; R C Heel; T M Speight; G S Avery
Journal: Drugs Date: 1978-08 Impact factor: 9.546

2. Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.

Authors: J M Gumpel
Journal: Ann Rheum Dis Date: 1978-08 Impact factor: 19.103

Sulindac. Trials of a new anti-inflammatory drug.

1. [Proceedings: Double-blind comparison of MK 231 with indomethacin in spondylitis ankylopoetica].

2. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

3. Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis.

4. Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.

5. Sulindac in osteoarthrosis of the hip.

Review 1. Sulindac: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.

2. Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.

3. Outcome measurement in osteoarthritis clinical trials: the case for standardisation.

Review 4. Antirheumatic drugs: clinical pharmacology and therapeutic use.

5. An objective measurement of change in morning stiffness.

6. Studies on the metabolism and biological activity of the epimers of sulindac.

7. Variations in responses to non-steroidal anti-inflammatory drugs.