Ellen C Francis1, Dana Dabelea2,3,4, Kartik Shankar4, Wei Perng2,3,5. 1. Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA. Ellen.Francis@CUAnschutz.edu. 2. Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA. 3. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA. 4. Department of Pediatrics, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA. 5. Department of Nutritional Sciences, University of Michigan SPH, Ann Arbor, MI, USA.
Abstract
AIMS/HYPOTHESIS: Limited data exist on the association between maternal diet quality during pregnancy and metabolic traits in offspring during early childhood, which is a sensitive period for risk of obesity-related disorders later in life. We aimed to examine the association of maternal diet quality, as indicated by the Healthy Eating Index-2010 (HEI), in pregnancy with offspring metabolic biomarkers and body composition at age 4-7 years. METHODS: We used data from 761 mother-offspring pairs from the Healthy Start study to examine sex-specific associations of HEI >57 vs ≤57 with offspring fasting glucose, leptin, cholesterol, HDL, LDL, percentage fat mass, BMI z score and log-transformed insulin, 1/insulin, HOMA-IR, adiponectin, triacylglycerols, triacylglycerols:HDL, fat mass, and sum of skinfolds. Multivariable linear regression models accounted for maternal race/ethnicity, age, education, smoking habits during pregnancy and physical activity, and child's age. RESULTS: During pregnancy, mean (SD) HEI score was 55.0 (13.3), and 43.0% had an HEI score >57. Among boys, there was an inverse association of maternal HEI with offspring glucose, insulin, HOMA-IR and adiponectin. For instance, maternal HEI >57 was associated with lower fasting glucose (-0.11; 95% CI -0.20, -0.02 mmol/l), and lower concentrations of: insulin by 15.3% (95% CI -24.6, -5.0), HOMA-IR by 16.3% (95% CI -25.7, -5.6) and adiponectin by 9.3% (95% CI -16.1, -2.0). Among girls, there was an inverse association of maternal HEI with insulin and a positive association with LDL. However, following covariate adjustment, all estimates among girls were attenuated to the null. CONCLUSIONS/ INTERPRETATION: Greater compliance with the USA Dietary Guidelines via the HEI may improve the maternal-fetal milieu and decrease susceptibility for poor metabolic health among offspring, particularly boys. Future studies are warranted to confirm these associations and determine the underlying mechanisms.
AIMS/HYPOTHESIS: Limited data exist on the association between maternal diet quality during pregnancy and metabolic traits in offspring during early childhood, which is a sensitive period for risk of obesity-related disorders later in life. We aimed to examine the association of maternal diet quality, as indicated by the Healthy Eating Index-2010 (HEI), in pregnancy with offspring metabolic biomarkers and body composition at age 4-7 years. METHODS: We used data from 761 mother-offspring pairs from the Healthy Start study to examine sex-specific associations of HEI >57 vs ≤57 with offspring fasting glucose, leptin, cholesterol, HDL, LDL, percentage fat mass, BMI z score and log-transformed insulin, 1/insulin, HOMA-IR, adiponectin, triacylglycerols, triacylglycerols:HDL, fat mass, and sum of skinfolds. Multivariable linear regression models accounted for maternal race/ethnicity, age, education, smoking habits during pregnancy and physical activity, and child's age. RESULTS: During pregnancy, mean (SD) HEI score was 55.0 (13.3), and 43.0% had an HEI score >57. Among boys, there was an inverse association of maternal HEI with offspring glucose, insulin, HOMA-IR and adiponectin. For instance, maternal HEI >57 was associated with lower fasting glucose (-0.11; 95% CI -0.20, -0.02 mmol/l), and lower concentrations of: insulin by 15.3% (95% CI -24.6, -5.0), HOMA-IR by 16.3% (95% CI -25.7, -5.6) and adiponectin by 9.3% (95% CI -16.1, -2.0). Among girls, there was an inverse association of maternal HEI with insulin and a positive association with LDL. However, following covariate adjustment, all estimates among girls were attenuated to the null. CONCLUSIONS/ INTERPRETATION: Greater compliance with the USA Dietary Guidelines via the HEI may improve the maternal-fetal milieu and decrease susceptibility for poor metabolic health among offspring, particularly boys. Future studies are warranted to confirm these associations and determine the underlying mechanisms.
Authors: Patricia M Guenther; Sharon I Kirkpatrick; Jill Reedy; Susan M Krebs-Smith; Dennis W Buckman; Kevin W Dodd; Kellie O Casavale; Raymond J Carroll Journal: J Nutr Date: 2014-01-22 Impact factor: 4.798
Authors: Jiude Mao; Xia Zhang; Paizlee T Sieli; Michael T Falduto; Karen E Torres; Cheryl S Rosenfeld Journal: Proc Natl Acad Sci U S A Date: 2010-03-08 Impact factor: 11.205
Authors: Margaret Parker; Sheryl L Rifas-Shiman; Mandy B Belfort; Elsie M Taveras; Emily Oken; Christos Mantzoros; Matthew W Gillman Journal: J Pediatr Date: 2010-09-19 Impact factor: 4.406
Authors: Stefanie N Hinkle; Cuilin Zhang; Katherine L Grantz; Anthony Sciscione; Deborah A Wing; William A Grobman; Roger B Newman; Mary E D'Alton; Daniel Skupski; Michael P Nageotte; Angela C Ranzini; John Owen; Edward K Chein; Sabrina Craigo; Samrawit F Yisahak; Aiyi Liu; Paul S Albert; Germaine M Buck Louis; Jagteshwar Grewal Journal: Curr Dev Nutr Date: 2020-12-24
Authors: Nolwenn Regnault; Matthew W Gillman; Sheryl L Rifas-Shiman; Emma Eggleston; Emily Oken Journal: Diabetes Care Date: 2013-07-22 Impact factor: 19.112
Authors: Susanne Strohmaier; Leonie Helen Bogl; A Heather Eliassen; Jennifer Massa; Alison E Field; Jorge E Chavarro; Ming Ding; Rulla M Tamimi; Eva Schernhammer Journal: Eur J Epidemiol Date: 2020-03-17 Impact factor: 8.082
Authors: Aynaz Tajaddini; Michael D Kendig; Kelly V Prates; R Frederick Westbrook; Margaret J Morris Journal: Int J Mol Sci Date: 2022-01-27 Impact factor: 5.923
Authors: Satvinder K Dhaliwal; Dana Dabelea; Angela E Lee-Winn; Deborah H Glueck; Greta Wilkening; Wei Perng Journal: Womens Health Rep (New Rochelle) Date: 2022-08-04