Nadeeka N Dissanayaka1,2,3, Elana J Forbes4,5, Ji Hyun J Yang4, Dana Pourzinal4, John D O'Sullivan4,6, Leander K Mitchell5, David A Copland4,7, Katie L McMahon8, Gerard J Byrne4,9. 1. UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Building 71/918 Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, 4029, Australia. n.dissanayaka@uq.edu.au. 2. School of Psychology, The University of Queensland, Brisbane, Australia. n.dissanayaka@uq.edu.au. 3. Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Australia. n.dissanayaka@uq.edu.au. 4. UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Building 71/918 Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, 4029, Australia. 5. School of Psychology, The University of Queensland, Brisbane, Australia. 6. Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Australia. 7. School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. 8. School of Clinical Sciences, Queensland University of Technology, Brisbane, Australia. 9. Mental Health Service, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Abstract
INTRODUCTION: Preliminary evidence has demonstrated a link between anxiety and memory impairment in Parkinson's disease (PD). This study further investigated this association using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for anxiety disorders and a standardized cognitive test battery. METHODS: A convenience sample of 89 PD patients without dementia was recruited from neurology outpatient clinics. A cross-sectional design was applied. Participants completed two semi-structured interviews. The first interview diagnosed DSM-5 anxiety disorders, unspecified anxiety disorder, and no anxiety. The second interview applied a neurocognitive test battery comprising two tests for each domain. Logistic regression models compared cognitive characteristics associated with anxiety disorders to no anxiety. RESULTS: Clinically significant anxiety was associated with immediate verbal memory impairment compared to the no anxiety group (OR, 95% CI 0.52, 0.30-0.89; p = 0.018), controlling for sex and age. The anxiety disorders group demonstrated immediate (OR, 95% CI 0.46, 0.26-0.83; p = 0.010) and delayed (OR, 95% CI 0.63, 0.40-0.99; p = 0.047) verbal memory impairments compared to those without anxiety, controlling for sex and age. This association remained for immediate (OR, 95% CI 0.43, 0.22-0.84; p = 0.013), but not delayed verbal memory impairment (OR, 95% CI 0.65, 0.39-1.06; p = 0.081) when additionally controlling for disease severity, education and levodopa dose. CONCLUSION: These findings present first evidence that anxiety disorders are associated with verbal memory impairment in PD and have implications for the management and treatment of anxiety in PD.
INTRODUCTION: Preliminary evidence has demonstrated a link between anxiety and memory impairment in Parkinson's disease (PD). This study further investigated this association using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for anxiety disorders and a standardized cognitive test battery. METHODS: A convenience sample of 89 PD patients without dementia was recruited from neurology outpatient clinics. A cross-sectional design was applied. Participants completed two semi-structured interviews. The first interview diagnosed DSM-5 anxiety disorders, unspecified anxiety disorder, and no anxiety. The second interview applied a neurocognitive test battery comprising two tests for each domain. Logistic regression models compared cognitive characteristics associated with anxiety disorders to no anxiety. RESULTS: Clinically significant anxiety was associated with immediate verbal memory impairment compared to the no anxiety group (OR, 95% CI 0.52, 0.30-0.89; p = 0.018), controlling for sex and age. The anxiety disorders group demonstrated immediate (OR, 95% CI 0.46, 0.26-0.83; p = 0.010) and delayed (OR, 95% CI 0.63, 0.40-0.99; p = 0.047) verbal memory impairments compared to those without anxiety, controlling for sex and age. This association remained for immediate (OR, 95% CI 0.43, 0.22-0.84; p = 0.013), but not delayed verbal memory impairment (OR, 95% CI 0.65, 0.39-1.06; p = 0.081) when additionally controlling for disease severity, education and levodopa dose. CONCLUSION: These findings present first evidence that anxiety disorders are associated with verbal memory impairment in PD and have implications for the management and treatment of anxiety in PD.
Authors: Jennifer Y Y Szeto; Loren Mowszowski; Moran Gilat; Courtney C Walton; Sharon L Naismith; Simon J G Lewis Journal: J Parkinsons Dis Date: 2016-05-07 Impact factor: 5.568
Authors: Gregory M Pontone; Nadeeka Dissanayaka; Liana Apostolova; Richard G Brown; Roseanne Dobkin; Kathy Dujardin; Joseph H Friedman; Albert F G Leentjens; Eric J Lenze; Laura Marsh; Lynda Mari; Oury Monchi; Irene H Richard; Anette Schrag; Antonio P Strafella; Beth Vernaleo; Daniel Weintraub; Zoltan Mari Journal: NPJ Parkinsons Dis Date: 2020-06-02
Authors: Daniel Weintraub; Tanya Simuni; Chelsea Caspell-Garcia; Christopher Coffey; Shirley Lasch; Andrew Siderowf; Dag Aarsland; Paolo Barone; David Burn; Lama M Chahine; Jamie Eberling; Alberto J Espay; Eric D Foster; James B Leverenz; Irene Litvan; Irene Richard; Matthew D Troyer; Keith A Hawkins Journal: Mov Disord Date: 2015-03-04 Impact factor: 10.338
Authors: Nadeeka N W Dissanayaka; Anna Sellbach; Sally Matheson; John D O'Sullivan; Peter A Silburn; Gerard J Byrne; Rodney Marsh; George D Mellick Journal: Mov Disord Date: 2010-05-15 Impact factor: 10.338
Authors: Martijn P G Broen; Nadia E Narayen; Mark L Kuijf; Nadeeka N W Dissanayaka; Albert F G Leentjens Journal: Mov Disord Date: 2016-04-29 Impact factor: 10.338
Authors: Nadeeka N W Dissanayaka; Elizabeth White; John D O'Sullivan; Rodney Marsh; Peter A Silburn; David A Copland; George D Mellick; Gerard J Byrne Journal: Mov Disord Clin Pract Date: 2015-04-06
Authors: Alison J Yarnall; David P Breen; Gordon W Duncan; Tien K Khoo; Shirley Y Coleman; Michael J Firbank; Cristina Nombela; Sophie Winder-Rhodes; Jonathan R Evans; James B Rowe; Brit Mollenhauer; Niels Kruse; Gavin Hudson; Patrick F Chinnery; John T O'Brien; Trevor W Robbins; Keith Wesnes; David J Brooks; Roger A Barker; David J Burn Journal: Neurology Date: 2013-12-20 Impact factor: 9.910